Protein: ENSP00000280700
Gene: NGLY1

LinkedOmicsKB © 2022-2023 Zhang Lab

NGLY1:
N-glycanase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T136AASTQLPTTPSSNPS444--------635443----172
T137ASTQLPTTPSSNPSG395------9-------204--557
S139TQLPTTPSSNPSGLN18------------------53
S140QLPTTPSSNPSGLNQ233----------1010------112
T449VEFISPKTPKPGELG19------9-------------
Showing 1 to 5 of 5 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T136AASTQLPTTPSSNPS-----------
T137ASTQLPTTPSSNPSG-----------
S139TQLPTTPSSNPSGLN-----------
S140QLPTTPSSNPSGLNQ-----------
T449VEFISPKTPKPGELG-----------
Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK2T1376.9e-3--------0.85-6.0e-5
KINASE-PSP_CDK1T1378.4e-3-------0.79-5.5e-4
KINASE-PSP_MAPKAPK2T1370.012-------0.11-0.054
PERT-PSP_NOCODAZOLET1370.012--------0.65-6.4e-5
DISEASE-PSP_Alzheimer's_diseaseT1370.012---------0.012
HALLMARK_GLYCOLYSIST1370.018-------0.6-4.9e-3
HALLMARK_PI3K_AKT_MTOR_SIGNALINGT1360.02---------0.02
cibersort: T cell regulatory (Tregs)S1400.025-----0.68---5.7e-3
KINASE-PSP_ERK2/MAPK1T1370.03-------0.32-0.037
SBS1 (clock-like)S1400.034-----0.35---0.038
Showing 1 to 10 of 1290 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT136T137S139S140T449proteinRNASCNVmethylationCCRCCT136T137S139S140T449proteinRNASCNVmethylationCOADT136T137S139S140T449proteinRNASCNVmethylationGBMT136T137S139S140T449proteinRNASCNVmethylationHNSCCT136T137S139S140T449proteinRNASCNVmethylationLSCCT136T137S139S140T449proteinRNASCNVmethylationLUADT136T137S139S140T449proteinRNASCNVmethylationOVT136T137S139S140T449proteinRNASCNVmethylationPDACT136T137S139S140T449proteinRNASCNVmethylationUCECT136T137S139S140T449proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
MTMR2T137-8.9e-4----------8.9e-4
G6PC3T137-2.3e-3--------0.039--0.024
UBLCP1T137-2.8e-3--------0.085--0.012
IMPA1S140-3.3e-3------2.7e-3----0.25
UBASH3BS140-4.7e-3------0.18----8.1e-3
PTPRDT136-9.1e-3----------9.1e-3
SSH1T136-0.01----------0.01
MTMR1T136-0.015----------0.015
DUSP1S140-0.018------0.018----
PTPRUS140-0.018------0.049----0.17
Showing 1 to 10 of 1200 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.