YAP1: Yes1 associated transcriptional regulator
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1jmq chain A
1k5r chain A
1k9q chain A
1k9r chain A
2law chain A
2lax chain A
2lay chain A
2ltv chain A
2ltw chain A
3kys chain B
3kys chain D
3mhr chain P
4re1 chain C
4re1 chain D
4rex chain A
5oaq chain L
5ydx chain A
5ydy chain A
6g6x chain P
6g8i chain P
6g8j chain P
6g8k chain P
6g8l chain P
6g8p chain P
6g8q chain P
6ge3 chain L
6ge4 chain L
6ge5 chain L
6ge6 chain L
6gec chain L
6gee chain L
6geg chain L
6gei chain L
6gek chain L
6gek chain M
6hik chain L
6hil chain L
6hil chain M
6hil chain N
6hil chain O
6q2x chain L
7o07 chain P
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S61 IVHVRGDS ETDLEAL 9 1334 104 - 103 80 - - 99 - 108 62 108 99 110 101 81 17 105 44 95 18 T63 HVRGDSET DLEALFN 6 422 41 - 52 32 - - - - 57 34 15 13 74 69 - - 24 11 - - S94 RLRKLPDS FFKPPEP 5 190 17 - - - - - - - 38 21 28 25 - - - - 18 7 31 5 S105 PPEPKSHS RQASTDA 8 336 9 - 45 25 - - 63 - 36 26 28 26 4 4 - - 25 12 24 9 S109 KSHSRQAS TDAGTAG 9 221 6 - 29 12 - - 18 - 15 10 15 13 16 16 32 9 11 5 11 3 T110 SHSRQAST DAGTAGA 9 1233 90 - 99 76 - - 71 - 104 58 99 90 101 93 83 19 105 44 83 18 T114 QASTDAGT AGALTPQ 5 91 25 - 25 16 - - - - - - - - 5 4 7 1 - - 5 3 T119 AGTAGALT PQHVRAH 9 421 30 - 8 - - - 36 - 24 13 30 27 23 20 74 18 8 3 89 18 S127 PQHVRAHS SPASLQL 8 165 17 - - - - - 36 - 16 8 5 5 9 9 35 4 5 1 13 2 S128 QHVRAHSS PASLQLG 9 674 49 - 46 34 - - 17 - 63 36 62 58 55 47 44 10 69 27 46 11
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S61 IVHVRGDS ETDLEAL -1e-13 - -0.011 - - -8.8e-8 -4.5e-17 -2.9e-6 -0.66 0.17 0.7 T63 HVRGDSET DLEALFN -8.2e-5 - -0.16 - - -0.009 - -1.5e-3 - -0.49 - S94 RLRKLPDS FFKPPEP -0.04 - - - - -0.44 -0.034 - - - - S105 PPEPKSHS RQASTDA 3.3e-3 - 9.3e-5 - - -0.82 -0.42 - - 2.7e-3 - S109 KSHSRQAS TDAGTAG 0.025 - 0.025 - - - - - - - - T110 SHSRQAST DAGTAGA -0.22 - -0.28 - - 3.9e-7 -2.7e-10 -0.065 -0.47 0.052 -0.79 T114 QASTDAGT AGALTPQ 0.22 - 0.22 - - - - - - - - T119 AGTAGALT PQHVRAH 0.62 - - - - -0.25 -0.6 -0.36 0.072 - 0.057 S127 PQHVRAHS SPASLQL - - - - - - - - - - - S128 QHVRAHSS PASLQLG -4.6e-3 - 6.5e-4 - - -0.24 -1.7e-9 -5.2e-4 -0.084 0.31 0.64
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S61
T63
S94
S105
S109
T110
T114
T119
S127
S128
S131
S138
T141
T143
S149
T154
S163
S164
S184
S274
S276
S289
S298
S340
T361
S366
S367
S371
S381
S382
S388
S393
S397
T398
S400
S403
S405
T412
S419
T425
T428
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation CCRCC S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation COAD S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation GBM S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation HNSCC S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation LSCC S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation LUAD S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation OV S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation PDAC S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation UCEC S61 T63 S94 S105 S109 T110 T114 T119 S127 S128 S131 S138 T141 T143 S149 T154 S163 S164 S184 S274 S276 S289 S298 S340 T361 S366 S367 S371 S381 S382 S388 S393 S397 T398 S400 S403 S405 T412 S419 T425 T428 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S61
T63
S94
S105
S109
T110
T114
T119
S127
S128
S131
S138
T141
T143
S149
T154
S163
S164
S184
S274
S276
S289
S298
S340
T361
S366
S367
S371
S381
S382
S388
S393
S397
T398
S400
S403
S405
T412
S419
T425
T428
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S61
T63
S94
S105
S109
T110
T114
T119
S127
S128
S131
S138
T141
T143
S149
T154
S163
S164
S184
S274
S276
S289
S298
S340
T361
S366
S367
S371
S381
S382
S388
S393
S397
T398
S400
S403
S405
T412
S419
T425
T428
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.