Protein: ENSP00000283027
Gene: NUBP1

LinkedOmicsKB © 2022-2023 Zhang Lab

NUBP1:
nucleotide binding protein 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S21AQAGRGASCQGCPNQ5267--77561223----15142416273----
S33PNQRLCASGAGATPD6247--44--9---74683129--32185
T38CASGAGATPDTAIEE515113-87------151488----6711
S242CPKCKKESQIFPPTT217--44--9-------------
S290FFIDAPDSPATLAYR18--44----------------
S312EFCNLHQSKEENLIS101263113-99765490-1015910394110101439105448918
Showing 1 to 6 of 6 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S21AQAGRGASCQGCPNQ0.045--0.25----6.7e-5---
S33PNQRLCASGAGATPD-7.8e-25------8.8e-22-7e-7---
T38CASGAGATPDTAIEE0.12---------0.12
S242CPKCKKESQIFPPTT-----------
S290FFIDAPDSPATLAYR-----------
S312EFCNLHQSKEENLIS0.24--4.2e-5---9.4e-32.9e-111.4e-20--3.2e-90.52
Showing 1 to 6 of 6 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_BILE_ACID_METABOLISMS3124.3e-91.4e-44.5e-4--0.10.30.645.4e-50.363.2e-30.011
HALLMARK_PEROXISOMES3125.3e-73.5e-51.9e-5--1.9e-30.270.670.0110.720.0020.028
KINASE-PSP_PKACA/PRKACAS334.5e-6-----5.6e-60.075--0.1
xcell: T cell CD8+S216.0e-6-0.220.59--2.7e-55.6e-30.17--
PATH-NP_EGFR1_PATHWAYS333.6e-5-----6.0e-40.017--0.18
KINASE-PSP_PKACA/PRKACAS211.1e-4-0.0350.032--0.160.0310.4--
KINASE-PSP_AurB/AURKBS331.3e-4-----1.1e-30.69--3.1e-3
HALLMARK_IL2_STAT5_SIGNALINGS331.3e-4-----9.4e-40.018--0.35
xcell: T cell CD8+ central memoryS211.7e-4-0.20.071--2.6e-40.042-0.72--
xcell: Class-switched memory B cellS212.8e-4-0.0410.099--0.0110.780.11--
Showing 1 to 10 of 1548 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS21S33T38S242S290S312proteinRNASCNVmethylationCCRCCS21S33T38S242S290S312proteinRNASCNVmethylationCOADS21S33T38S242S290S312proteinRNASCNVmethylationGBMS21S33T38S242S290S312proteinRNASCNVmethylationHNSCCS21S33T38S242S290S312proteinRNASCNVmethylationLSCCS21S33T38S242S290S312proteinRNASCNVmethylationLUADS21S33T38S242S290S312proteinRNASCNVmethylationOVS21S33T38S242S290S312proteinRNASCNVmethylationPDACS21S33T38S242S290S312proteinRNASCNVmethylationUCECS21S33T38S242S290S312proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PTPRJS312-2.6e-13-1.8e-4-5.4e-4--8.6e-4-0.650.08-6.2e-4-0.093-2.2e-3-6.2e-6
NT5DC2S312-5.4e-8-0.098-1.9e-5-0.65-0.12-0.01-0.150.6-3.2e-3-4.6e-3
BPGMS312-1.2e-6-0.32-5.2e-5--1.4e-3-0.067-0.480.19-0.18-0.22-0.011
PTPN2S312-2.7e-6-0.89-0.07--5.9e-30.590.77-0.046-3.1e-3-0.026-2.3e-3
PPM1FS312-2.1e-5-0.055-0.12--0.037-0.92-3.9e-30.61-0.011-0.0210.89
NT5C1AS21-2.4e-5--2.4e-5--------
DUSP14S21-2.5e-5--4.6e-5----0.058----
TIMM50T38-3.9e-5-0.034-----0.056----0.002
PTPN7S312-4.6e-5-0.019-5.4e-3--9.1e-30.150.13-0.066-0.19-0.012-0.078
CTDSP1S21-8.1e-5--4.4e-6----0.022-0.69-0.54--
Showing 1 to 10 of 1440 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.