Protein: ENSP00000285071
Gene: FLCN

LinkedOmicsKB © 2022-2023 Zhang Lab

FLCN:
folliculin

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38QGDGNEDSPGQGEQA735718-1716--26-412251475349----134
S62NSRMRAHSPAEGASV101338113-90769710072-9556635893848319105447218
S68HSPAEGASVESSSPG2178-----------45------
S71AEGASVESSSPGPKK3659-1514--------1512------
S72EGASVESSSPGPKKS81246-12245--126202054--9469
S73GASVESSSPGPKKSD922324-44121453---19184429674192
S296LADLEEESESWDNSE112------------------12-
S298DLEEESESWDNSEAE927573-2423151254-1185598--16462
S302ESESWDNSEAEEEEK91204113-9171394290-1086293858780--102428316
S331QGPAESSSLSGCGSW383------9---------824618
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38QGDGNEDSPGQGEQA-2.7e-10-----4.4e-7-0.04-1.3e-4---
S62NSRMRAHSPAEGASV-7.7e-3--0.14-3.4e-3-2.1e-4-0.027-0.570.11-0.004-5.3e-3
S68HSPAEGASVESSSPG-----------
S71AEGASVESSSPGPKK-----------
S72EGASVESSSPGPKKS0.22-----0.22----
S73GASVESSSPGPKKSD-----------
S296LADLEEESESWDNSE-----------
S298DLEEESESWDNSEAE-0.34--0.34--------
S302ESESWDNSEAEEEEK-3.7e-17--1.8e-3-0.17-0.4-1.2e-15-2.7e-6--5.4e-6-0.17
S331QGPAESSSLSGCGSW1.8e-3---------1.8e-3
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationCCRCCS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationCOADS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationGBMS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationHNSCCS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationLSCCS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationLUADS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationOVS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationPDACS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylationUCECS38S62S68S71S72S73S296S298S302S331S333S337S563S571proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.