USP43: ubiquitin specific peptidase 43
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S228 SENCLSPS AQLPLGQ 2 59 - - - - - - - - 36 16 - - - - - - 5 2 - - S249 FQAQYRSS LTCPHCL 1 10 - - - - - - - - - - - - - - - - - - 10 - Y330 EVILVELY PSGFQRS 6 433 87 - 70 56 25 28 - - - - 29 27 44 41 - - - - 23 3 S332 ILVELYPS GFQRSFF 6 433 87 - 70 56 25 28 - - - - 29 27 44 41 - - - - 23 3 S391 EGQRFSLS LHSESKV 1 7 - - - - - - - - - - - - - - - - - - 7 - Y470 GLSVACSY LSPKDSR 5 90 - - 14 12 - - - - - - 5 4 9 8 - - 5 2 29 2 S472 SVACSYLS PKDSRPL 1 6 - - - - - - - - - - - - - - - - - - 6 - S623 APHVAQRS TSPEAGL 3 54 - - - - - - 36 - - - - - 4 4 - - 6 4 - - S625 HVAQRSTS PEAGLGP 10 657 24 - 31 15 16 20 54 - 34 20 60 55 93 84 22 3 9 4 95 18 S740 HWLLRLGS HAGSTRG 5 81 - - - - - - - - 14 5 10 10 8 8 8 1 - - 13 4
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S228 SENCLSPS AQLPLGQ -3.1e-5 - - - - -3.1e-5 - - - - - S249 FQAQYRSS LTCPHCL - - - - - - - - - - - Y330 EVILVELY PSGFQRS -0.57 - 2.4e-5 -0.039 - - -5.0e-4 0.85 - - - S332 ILVELYPS GFQRSFF -0.57 - 2.4e-5 -0.039 - - -5.0e-4 0.85 - - - S391 EGQRFSLS LHSESKV - - - - - - - - - - - Y470 GLSVACSY LSPKDSR - - - - - - - - - - - S472 SVACSYLS PKDSRPL - - - - - - - - - - - S623 APHVAQRS TSPEAGL - - - - - - - - - - - S625 HVAQRSTS PEAGLGP -6.5e-11 - -0.12 - - -0.18 -7.5e-17 -1.6e-7 - - 0.062 S740 HWLLRLGS HAGSTRG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S228
S249
Y330
S332
S391
Y470
S472
S623
S625
S740
S744
S754
S759
S766
S794
T812
S818
S844
T845
S846
S848
S851
S876
S938
S965
S966
S969
Y971
S1024
S1027
S1031
S1041
S1065
S1068
S1069
S1088
S1111
T1117
S1122
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation CCRCC S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation COAD S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation GBM S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation HNSCC S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation LSCC S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation LUAD S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation OV S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation PDAC S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation UCEC S228 S249 Y330 S332 S391 Y470 S472 S623 S625 S740 S744 S754 S759 S766 S794 T812 S818 S844 T845 S846 S848 S851 S876 S938 S965 S966 S969 Y971 S1024 S1027 S1031 S1041 S1065 S1068 S1069 S1088 S1111 T1117 S1122 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S228
S249
Y330
S332
S391
Y470
S472
S623
S625
S740
S744
S754
S759
S766
S794
T812
S818
S844
T845
S846
S848
S851
S876
S938
S965
S966
S969
Y971
S1024
S1027
S1031
S1041
S1065
S1068
S1069
S1088
S1111
T1117
S1122
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S228
S249
Y330
S332
S391
Y470
S472
S623
S625
S740
S744
S754
S759
S766
S794
T812
S818
S844
T845
S846
S848
S851
S876
S938
S965
S966
S969
Y971
S1024
S1027
S1031
S1041
S1065
S1068
S1069
S1088
S1111
T1117
S1122
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.