Protein: ENSP00000285814
Gene: NIFK

LinkedOmicsKB © 2022-2023 Zhang Lab

NIFK:
nucleolar protein interacting with the FHA domain of MKI67

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S218RKKKKKVSGTLDTPE3229---------------4162
T220KKKKVSGTLDTPEKT119--------127----------
T223KVSGTLDTPEKTVDS101316122-6142797390-108621039510192621482347818
T227TLDTPEKTVDSQGPT272----2529--------153----
S230TPEKTVDSQGPTPVC6859---63--20954--71--192
T234TVDSQGPTPVCTPTF1043938-44423918-101601094441112311119
T238QGPTPVCTPTFLERR1077626-44746181-291740394036681392399518
S247TFLERRKSQVAELND101295113-103804599-1086210899110101338105449518
T279EEIQETQTPTHSRKK952326-435410-2314686384756814--4913
Showing 1 to 9 of 9 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S218RKKKKKVSGTLDTPE-----------
T220KKKKVSGTLDTPEKT-----------
T223KVSGTLDTPEKTVDS4.2e-61-1.4e-36e-19-1.7e-211.8e-322.2e-220.2-0.484.5e-3
T227TLDTPEKTVDSQGPT0.15--0.15-------
S230TPEKTVDSQGPTPVC-----------
T234TVDSQGPTPVCTPTF-0.75--0.39-0.043---0.45-5.8e-3-
T238QGPTPVCTPTFLERR-0.49--0.035-0.890.250.22-0.78-1.6e-101.0e-4
S247TFLERRKSQVAELND1.2e-23-2.8e-26--3.7e-117.6e-151.5e-12--9.3e-6-0.002
T279EEIQETQTPTHSRKK9.5e-17----0.0532.3e-141.2e-70.016-0.19
Showing 1 to 9 of 9 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationCCRCCS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationCOADS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationGBMS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationHNSCCS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationLSCCS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationLUADS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationOVS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationPDACS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylationUCECS218T220T223T227S230T234T238S247T279proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.