TIAM1: TIAM Rac1 associated GEF 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2d8i chain A
3kzd chain A
3kze chain A
3kze chain B
3kze chain C
4gvc chain A
4gvd chain A
4gvd chain B
4k2o chain A
4k2p chain A
4k2p chain B
4k2p chain C
4k2p chain D
4nxp chain A
4nxq chain A
4nxq chain B
4nxq chain C
4nxr chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S29 GRKHTSRS LRLSHKT 4 213 - - - - - - 54 - 45 26 - - - - - - 37 15 29 7 S33 TSRSLRLS HKTRRTR 3 161 - - - - - - 54 - 45 26 - - - - - - - - 29 7 S52 GKVIHRNS EVSTRSS 10 975 52 - 25 22 43 55 89 - 101 59 94 87 78 73 28 5 98 41 12 13 S55 IHRNSEVS TRSSSTP 7 353 36 - - - - - 84 - 19 10 55 50 23 20 - - 33 14 - 9 S58 NSEVSTRS SSTPSIP 1 18 - - - - - - 18 - - - - - - - - - - - - - S60 EVSTRSSS TPSIPQS 3 24 - - - - - - 8 - 5 3 - - 4 4 - - - - - - T61 VSTRSSST PSIPQSL 1 8 - - - - - - - - - - - - 4 4 - - - - - - S151 EGGRRQHS YTSNGPT 1 9 - - - - - - 9 - - - - - - - - - - - - - T162 NGPTFMET ASFKKKR 3 70 22 - - - - - - - 25 11 - - - - - - 9 3 - - S164 PTFMETAS FKKKRSK 2 45 - - - - - - 36 - - - - - - - 7 2 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S29 GRKHTSRS LRLSHKT -0.2 - - - - -0.001 - - - 0.14 - S33 TSRSLRLS HKTRRTR -0.001 - - - - -0.001 - - - - - S52 GKVIHRNS EVSTRSS 0.011 - 4.8e-9 -0.61 - 0.3 -2.9e-4 0.58 - 0.003 - S55 IHRNSEVS TRSSSTP -0.012 - - - - - -0.058 0.49 - -1.6e-3 - S58 NSEVSTRS SSTPSIP - - - - - - - - - - - S60 EVSTRSSS TPSIPQS - - - - - - - - - - - T61 VSTRSSST PSIPQSL - - - - - - - - - - - S151 EGGRRQHS YTSNGPT - - - - - - - - - - - T162 NGPTFMET ASFKKKR 0.5 - - - - 0.5 - - - - - S164 PTFMETAS FKKKRSK - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S29
S33
S52
S55
S58
S60
T61
S151
T162
S164
S172
S219
S224
S231
S298
S307
S309
S311
T319
T320
S329
S356
Y357
S358
S368
S370
S374
S695
S711
S726
S998
S1008
S1018
S1020
S1321
S1407
Y1414
S1437
T1456
S1463
S1465
S1466
S1506
S1519
S1534
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation CCRCC S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation COAD S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation GBM S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation HNSCC S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation LSCC S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation LUAD S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation OV S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation PDAC S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation UCEC S29 S33 S52 S55 S58 S60 T61 S151 T162 S164 S172 S219 S224 S231 S298 S307 S309 S311 T319 T320 S329 S356 Y357 S358 S368 S370 S374 S695 S711 S726 S998 S1008 S1018 S1020 S1321 S1407 Y1414 S1437 T1456 S1463 S1465 S1466 S1506 S1519 S1534 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S29
S33
S52
S55
S58
S60
T61
S151
T162
S164
S172
S219
S224
S231
S298
S307
S309
S311
T319
T320
S329
S356
Y357
S358
S368
S370
S374
S695
S711
S726
S998
S1008
S1018
S1020
S1321
S1407
Y1414
S1437
T1456
S1463
S1465
S1466
S1506
S1519
S1534
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S29
S33
S52
S55
S58
S60
T61
S151
T162
S164
S172
S219
S224
S231
S298
S307
S309
S311
T319
T320
S329
S356
Y357
S358
S368
S370
S374
S695
S711
S726
S998
S1008
S1018
S1020
S1321
S1407
Y1414
S1437
T1456
S1463
S1465
S1466
S1506
S1519
S1534
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.