HMGCR: 3-hydroxy-3-methylglutaryl-CoA reductase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1dq8 chain A
1dq8 chain B
1dq8 chain C
1dq8 chain D
1dq9 chain A
1dq9 chain B
1dq9 chain C
1dq9 chain D
1dqa chain A
1dqa chain B
1dqa chain C
1dqa chain D
1hw8 chain A
1hw8 chain B
1hw8 chain C
1hw8 chain D
1hw9 chain A
1hw9 chain B
1hw9 chain C
1hw9 chain D
1hwi chain A
1hwi chain B
1hwi chain C
1hwi chain D
1hwj chain A
1hwj chain B
1hwj chain C
1hwj chain D
1hwk chain A
1hwk chain B
1hwk chain C
1hwk chain D
1hwl chain A
1hwl chain B
1hwl chain C
1hwl chain D
2q1l chain A
2q1l chain B
2q1l chain C
2q1l chain D
2q6b chain A
2q6b chain B
2q6b chain C
2q6b chain D
2q6c chain A
2q6c chain B
2q6c chain C
2q6c chain D
2r4f chain A
2r4f chain B
2r4f chain C
2r4f chain D
3bgl chain A
3bgl chain B
3bgl chain C
3bgl chain D
3cct chain A
3cct chain B
3cct chain C
3cct chain D
3ccw chain A
3ccw chain B
3ccw chain C
3ccw chain D
3ccz chain A
3ccz chain B
3ccz chain C
3ccz chain D
3cd0 chain A
3cd0 chain B
3cd0 chain C
3cd0 chain D
3cd5 chain A
3cd5 chain B
3cd5 chain C
3cd5 chain D
3cd7 chain A
3cd7 chain B
3cd7 chain C
3cd7 chain D
3cda chain A
3cda chain B
3cda chain C
3cda chain D
3cdb chain A
3cdb chain B
3cdb chain C
3cdb chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S384 RNNQKCDS VEEETGI 3 35 - - - - 4 5 9 - - - - - - - - - - - 6 11 T409 PLVAETDT PNRATFV 1 8 - - - - - - - - - - - - - - - - - - 6 2 S421 TFVVGNSS LLDTSSV 8 255 21 - 4 4 47 43 9 - 34 19 10 9 19 16 - - 14 6 - - T425 GNSSLLDT SSVLVTQ 2 16 9 - - - - - - - 5 2 - - - - - - - - - - S504 QLLSKKLS EPSSLQY 6 386 - - - - 64 62 37 - 37 19 - - - - 22 5 42 16 64 18 S872 SHMIHNRS KINLQDL 2 211 - - - - 73 70 - - - - - - - - 55 13 - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S384 RNNQKCDS VEEETGI - - - - - - - - - - - T409 PLVAETDT PNRATFV - - - - - - - - - - - S421 TFVVGNSS LLDTSSV 0.037 - - 0.49 - 0.023 - - - - - T425 GNSSLLDT SSVLVTQ - - - - - - - - - - - S504 QLLSKKLS EPSSLQY 7.3e-12 - - 1.1e-10 - 9.1e-5 - - - 9.5e-4 0.97 S872 SHMIHNRS KINLQDL 2.2e-12 - - 1.2e-10 - - - - 4.8e-4 - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S384
T409
S421
T425
S504
S872
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation CCRCC S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation COAD S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation GBM S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation HNSCC S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation LSCC S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation LUAD S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation OV S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation PDAC S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation UCEC S384 T409 S421 T425 S504 S872 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S384
T409
S421
T425
S504
S872
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S384
T409
S421
T425
S504
S872
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.