APPL1: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ej8 chain A
2ej8 chain B
2ela chain A
2ela chain B
2elb chain A
2q12 chain A
2q13 chain A
2z0n chain A
2z0o chain A
5c5b chain A
5c5b chain C
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y283 NLTRKAGY LNARNKT 1 9 - - - - - - 9 - - - - - - - - - - - - - S393 TAARVNQS ALEAVTP 1 17 - - 9 8 - - - - - - - - - - - - - - - - T399 QSALEAVT PSPSFQQ 9 630 39 - 66 45 - - 9 - 54 35 40 37 68 61 18 7 43 18 75 15 S401 ALEAVTPS PSFQQRH 10 1134 9 - 9 8 92 96 99 - 74 44 98 90 79 72 83 19 105 44 95 18 S403 EAVTPSPS FQQRHES 7 254 - - - - 1 7 17 - 6 3 25 23 49 44 - - 20 12 36 11 S410 SFQQRHES LRPAAGQ 10 1367 112 - 103 80 89 90 99 - 103 59 98 89 106 98 14 2 92 36 79 18 S418 LRPAAGQS RPPTART 1 8 8 - - - - - - - - - - - - - - - - - - - T425 SRPPTART SSSGSLG 1 9 - - - - - - - - - - 5 4 - - - - - - - - S426 RPPTARTS SSGSLGS 3 26 - - 5 4 1 7 - - 7 2 - - - - - - - - - - S427 PPTARTSS SGSLGSE 8 85 - - - - 5 4 27 - 5 4 5 5 5 4 7 2 5 1 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y283 NLTRKAGY LNARNKT - - - - - - - - - - - S393 TAARVNQS ALEAVTP - - - - - - - - - - - T399 QSALEAVT PSPSFQQ -1e-12 - -1.1e-7 - - -0.6 -7.4e-3 -1.1e-5 - -0.1 -3.6e-3 S401 ALEAVTPS PSFQQRH -2.1e-13 - - -4.7e-9 - -3.8e-5 -3.1e-9 -1.6e-4 -0.025 2.3e-5 -0.078 S403 EAVTPSPS FQQRHES -0.28 - - - - - 0.12 -2.6e-5 - 0.04 -0.11 S410 SFQQRHES LRPAAGQ -0.053 - -6.4e-3 -2.4e-15 - 0.28 -0.072 4.1e-6 - 6.9e-7 -8.5e-4 S418 LRPAAGQS RPPTART - - - - - - - - - - - T425 SRPPTART SSSGSLG - - - - - - - - - - - S426 RPPTARTS SSGSLGS - - - - - - - - - - - S427 PPTARTSS SGSLGSE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
Y283
S393
T399
S401
S403
S410
S418
T425
S426
S427
S428
S430
S433
S435
T436
S442
S445
T451
S459
S485
S488
S491
T493
S595
S597
S636
S681
S689
S690
S691
S693
S696
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation CCRCC Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation COAD Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation GBM Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation HNSCC Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation LSCC Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation LUAD Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation OV Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation PDAC Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation UCEC Y283 S393 T399 S401 S403 S410 S418 T425 S426 S427 S428 S430 S433 S435 T436 S442 S445 T451 S459 S485 S488 S491 T493 S595 S597 S636 S681 S689 S690 S691 S693 S696 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
Y283
S393
T399
S401
S403
S410
S418
T425
S426
S427
S428
S430
S433
S435
T436
S442
S445
T451
S459
S485
S488
S491
T493
S595
S597
S636
S681
S689
S690
S691
S693
S696
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
Y283
S393
T399
S401
S403
S410
S418
T425
S426
S427
S428
S430
S433
S435
T436
S442
S445
T451
S459
S485
S488
S491
T493
S595
S597
S636
S681
S689
S690
S691
S693
S696
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.