SHANK1: SH3 and multiple ankyrin repeat domains 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6cpi chain A
6ywz chain A
6ywz chain B
6yx0 chain A
6yx0 chain B
6yx1 chain A
6yx1 chain B
6yx2 chain A
6yx2 chain B
7a00 chain A
7a00 chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S4 ____MTHS PATSEDE 1 56 - - - - - - 56 - - - - - - - - - - - - - S24 SECPEGGS ESDSSPD 1 18 - - - - - - 18 - - - - - - - - - - - - - S26 CPEGGSES DSSPDGP 1 18 - - - - - - 18 - - - - - - - - - - - - - S63 GLQGRSMS VPDDAHF 1 9 - - - - - - 9 - - - - - - - - - - - - - Y186 GLKKFLEY VQLGTSD 1 9 - - - - - - 9 - - - - - - - - - - - - - S413 DVVPFQES PKYAARR 2 106 - - - - - - 90 - - - - - - - - - - - 14 2 S519 QPRGRPSS SGTPREG 1 81 - - - - - - 81 - - - - - - - - - - - - - S615 LEEVANRS QESKQES 1 45 - - - - - - 45 - - - - - - - - - - - - - S788 TISLRSKS MTSELEE 2 89 - - - - - - 71 - - - - - - - - - - - 7 11 S861 GFFATESS FDPHHRA 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S4 ____MTHS PATSEDE - - - - - - - - - - - S24 SECPEGGS ESDSSPD - - - - - - - - - - - S26 CPEGGSES DSSPDGP - - - - - - - - - - - S63 GLQGRSMS VPDDAHF - - - - - - - - - - - Y186 GLKKFLEY VQLGTSD - - - - - - - - - - - S413 DVVPFQES PKYAARR - - - - - - - - - - - S519 QPRGRPSS SGTPREG - - - - - - - - - - - S615 LEEVANRS QESKQES - - - - - - - - - - - S788 TISLRSKS MTSELEE - - - - - - - - - - - S861 GFFATESS FDPHHRA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S4
S24
S26
S63
Y186
S413
S519
S615
S788
S861
S890
S1093
S1287
S1382
S1428
S1432
S1436
S1522
S1925
S2000
S2019
S2038
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation CCRCC S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation COAD S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation GBM S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation HNSCC S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation LSCC S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation LUAD S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation OV S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation PDAC S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation UCEC S4 S24 S26 S63 Y186 S413 S519 S615 S788 S861 S890 S1093 S1287 S1382 S1428 S1432 S1436 S1522 S1925 S2000 S2019 S2038 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S4
S24
S26
S63
Y186
S413
S519
S615
S788
S861
S890
S1093
S1287
S1382
S1428
S1432
S1436
S1522
S1925
S2000
S2019
S2038
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S4
S24
S26
S63
Y186
S413
S519
S615
S788
S861
S890
S1093
S1287
S1382
S1428
S1432
S1436
S1522
S1925
S2000
S2019
S2038
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.