Protein: ENSP00000294066
Gene: MAP4K2

LinkedOmicsKB © 2022-2023 Zhang Lab

MAP4K2:
mitogen-activated protein kinase kinase kinase kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S8MALLRDVSLQDPRDR18------8-------------
S129KGLHHLHSQGKIHRD243----------151387------
S170ASVAKRRSFIGTPYW16----------------51--
T296ASDPHLGTPSPEDCE513913-----70---5454----299
S298DPHLGTPSPEDCELE1054543-9871190-29148881363162846018
T326QHGPAERTPSEIQFH3388-----------1312--32--
S328GPAERTPSEIQFHQV101480122-10380918881-9757108991101017518100438918
S365LLGKEELSGSLLQSV119------19-------------
S367GKEELSGSLLQSVQE74199-1616--18-2816544810194--127--
S371LSGSLLQSVQEALEE110----------55--------
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S8MALLRDVSLQDPRDR-----------
S129KGLHHLHSQGKIHRD-----------
S170ASVAKRRSFIGTPYW-----------
T296ASDPHLGTPSPEDCE-----------
S298DPHLGTPSPEDCELE0.11----0.430.11-0.84--0.32
T326QHGPAERTPSEIQFH-----------
S328GPAERTPSEIQFHQV0.87--1.2e-6-0.75-3.9e-13-0.15-9.6e-100.0350.0090.77
S365LLGKEELSGSLLQSV-----------
S367GKEELSGSLLQSVQE-1.1e-22-----2.8e-3-1.1e-12-6e-12---
S371LSGSLLQSVQEALEE-----------
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationCCRCCS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationCOADS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationGBMS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationHNSCCS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationLSCCS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationLUADS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationOVS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationPDACS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylationUCECS8S129S170T296S298T326S328S365S367S371S385S387S394T398S423T427S437S438proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.