Protein: ENSP00000295006
Gene: CAPN2

LinkedOmicsKB © 2022-2023 Zhang Lab

CAPN2:
calpain 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S68KELGPYSSKTRGIEW7353--178--54-44295045--81622312-
S250DITSAADSEAITFQK18------------44------
S403EDEEDGESGCTFLVG110----------55--------
T406EDGESGCTFLVGLIQ219----------5554------
S462TNRARERSDTFINLR5119--2513--22---991411----133
Showing 1 to 5 of 5 rows

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S68KELGPYSSKTRGIEW-1.8e-11-----7.2e-6-7.4e-15--0.53-
S250DITSAADSEAITFQK-----------
S403EDEEDGESGCTFLVG-----------
T406EDGESGCTFLVGLIQ-----------
S462TNRARERSDTFINLR-9.9e-4--9.9e-4--------
Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESISS682.7e-9--0.63-7.1e-40.0231.2e-3--0.0014.1e-3
HALLMARK_APICAL_JUNCTIONS683.8e-8-0.47-0.0140.165.5e-6--9.2e-30.084
KINASE-PSP_PKCA/PRKCAS684e-8---1.3e-30.0170.031--0.0510.01
HALLMARK_COAGULATIONS684e-7--0.57-0.0560.171.9e-6--0.0592.4e-3
xcell: MonocyteS681.3e-6-0.67-0.0272.1e-32.2e-8---0.160.053
xcell: Endothelial cellS681.5e-6-0.84-0.0710.113.4e-5--0.340.002
HALLMARK_UV_RESPONSE_DNS683.8e-6-0.74-0.01-0.481.8e-5--0.111.2e-3
HALLMARK_P53_PATHWAYS684.5e-6-0.95-0.0686.2e-34.4e-4--0.320.035
ESTIMATE: StromalScoreS684.5e-6-0.77-5.2e-30.485.0e-5--0.712.7e-3
PROGENy: TGFbS686.9e-6-0.33-6.1e-30.420.016--0.0340.049
Showing 1 to 10 of 1290 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS68S250S403T406S462proteinRNASCNVmethylationCCRCCS68S250S403T406S462proteinRNASCNVmethylationCOADS68S250S403T406S462proteinRNASCNVmethylationGBMS68S250S403T406S462proteinRNASCNVmethylationHNSCCS68S250S403T406S462proteinRNASCNVmethylationLSCCS68S250S403T406S462proteinRNASCNVmethylationLUADS68S250S403T406S462proteinRNASCNVmethylationOVS68S250S403T406S462proteinRNASCNVmethylationPDACS68S250S403T406S462proteinRNASCNVmethylationUCECS68S250S403T406S462proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PPM1GS68-4.3e-11--0.12--4.8e-5-0.011-2.0e-4---0.28-1.4e-3
ILKAPS68-1.5e-7--0.29--4.9e-5-0.52-6.5e-5---0.5-0.015
EYA3S68-4.5e-6-0.38--0.0120.94-4.1e-4---6.8e-3-6.0e-4
RNGTTS462-2.9e-5--7.8e-4--0.076---0.18---0.061
PPM1GS462-5.5e-5--0.008--3.1e-3---0.21---0.23
PNKPS68-1.2e-4--0.043--0.1-3.7e-3-0.24---0.29-0.54
CTDP1S462-1.7e-4--0.089--3.7e-3---0.084---0.24
PNKPS462-1.8e-4--0.079--9.4e-4---0.11---0.4
CTDP1S68-2.2e-4--0.12--0.11-0.062-0.052---9.1e-30.57
DUSP11S68-2.3e-4--0.065--0.0150.93-0.096---0.58-9.1e-3
Showing 1 to 10 of 1200 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.