MERTK: MER proto-oncogene, tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2dbj chain A
2p0c chain A
2p0c chain B
3bpr chain A
3bpr chain B
3bpr chain C
3bpr chain D
3brb chain A
3brb chain B
3tcp chain A
3tcp chain B
4m3q chain A
4m3q chain B
4mh7 chain A
4mh7 chain B
4mha chain A
4mha chain B
5k0k chain A
5k0k chain B
5k0x chain A
5k0x chain B
5tc0 chain A
5tc0 chain B
5td2 chain A
5td2 chain B
5u6c chain A
5u6c chain B
6mep chain A
6mep chain B
7aax chain A
7aay chain A
7aaz chain A
7ab0 chain A
7ab1 chain A
7ab2 chain A
7avx chain A
7avx chain B
7avy chain A
7avz chain A
7aw0 chain A
7aw1 chain A
7aw2 chain A
7aw3 chain A
7aw4 chain A
7aw4 chain B
7cqe chain A
7cqe chain C
7dxl chain A
7dxl chain B
7m5z chain A
7m5z chain B
7oam chain A
7oam chain B
7ols chain A
7olv chain A
7olx chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S543 NAFTEEDS ELVVNYI 9 425 17 - 17 16 8 10 63 - 40 23 64 58 37 31 13 3 - - 23 2 S613 LKQEDGTS LKVAVKT 3 99 - - - - - - 36 - - - 15 13 - - - - - - 21 14 S935 RYILNGGS EEWEDLT 5 61 8 - 4 4 - - - - - - 10 9 9 8 - - - - - 9
Tumor and normal comparison
Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S543 NAFTEEDS ELVVNYI -2.4e-5 - - - - -5.9e-3 0.63 -4.5e-7 - - - S613 LKQEDGTS LKVAVKT -0.096 - - - - - - - - - -0.096 S935 RYILNGGS EEWEDLT - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
Loading, please wait
all sites
S543
S613
S935
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S543 S613 S935 protein RNA SCNV methylation CCRCC S543 S613 S935 protein RNA SCNV methylation COAD S543 S613 S935 protein RNA SCNV methylation GBM S543 S613 S935 protein RNA SCNV methylation HNSCC S543 S613 S935 protein RNA SCNV methylation LSCC S543 S613 S935 protein RNA SCNV methylation LUAD S543 S613 S935 protein RNA SCNV methylation OV S543 S613 S935 protein RNA SCNV methylation PDAC S543 S613 S935 protein RNA SCNV methylation UCEC S543 S613 S935 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S543
S613
S935
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S543
S613
S935
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.