Protein: ENSP00000295704
Gene: RNF25

LinkedOmicsKB © 2022-2023 Zhang Lab

RNF25:
ring finger protein 25

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T296TLAAELSTSPAVQST333----------5598----6-
S297LAAELSTSPAVQSTL4148----54--1611------4521397
S302STSPAVQSTLPPPLP219--------53------83--
T303TSPAVQSTLPPPLPV19------------54------
S450RPGTRRESLGLESKD101521122-10380928899-10258108991101018319101439518
Showing 1 to 5 of 5 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T296TLAAELSTSPAVQST-----------
S297LAAELSTSPAVQSTL-5.3e-8---------5.3e-8-
S302STSPAVQSTLPPPLP-----------
T303TSPAVQSTLPPPLPV-----------
S450RPGTRRESLGLESKD0.018-2.8e-28-2.9e-17-0.015-0.680.044.2e-30.43-1.0e-4
Showing 1 to 5 of 5 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_PKACA/PRKACAS4508.9e-620.0412.3e-98.4e-71.6e-81.8e-82.2e-162.2e-160.256.0e-68.9e-10
KINASE-PSP_PKCA/PRKCAS4506.1e-490.52-3.5e-41.5e-62.2e-162.2e-162.2e-160.843.7e-82.0e-6
KINASE-PSP_AurB/AURKBS4508.5e-33---5.5e-89.5e-82.2e-168.9e-5-0.051.3e-5
KINASE-PSP_Akt1/AKT1S4509.5e-330.0460.189.5e-81.4e-82.2e-97.9e-95.3e-5-0.95.6e-42.2e-5
PATH-NP_EGFR1_PATHWAYS4502.8e-24-0.670.90.20.422.4e-42.2e-162.2e-16-3.7e-43.7e-7
PERT-PSP_ANTI_CD3S4502e-22--1.6e-31.7e-31.1e-42.2e-16-0.729.1e-51.8e-3
PERT-PSP_EGFS4509.4e-210.3-0.688.5e-33.8e-51.5e-51.2e-101.3e-60.943.1e-44.1e-3
xcell: immune scoreS4501e-150.540.0320.0115.6e-43.5e-52.6e-55.1e-30.0230.0560.19
ESTIMATE: ImmuneScoreS4503.7e-150.830.0690.0161.3e-34.2e-53.4e-60.0290.0560.0310.026
xcell: MacrophageS4506.1e-150.540.231.2e-31.8e-46.8e-32.3e-60.321.9e-30.020.041
Showing 1 to 10 of 1290 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAT296S297S302T303S450proteinRNASCNVmethylationCCRCCT296S297S302T303S450proteinRNASCNVmethylationCOADT296S297S302T303S450proteinRNASCNVmethylationGBMT296S297S302T303S450proteinRNASCNVmethylationHNSCCT296S297S302T303S450proteinRNASCNVmethylationLSCCT296S297S302T303S450proteinRNASCNVmethylationLUADT296S297S302T303S450proteinRNASCNVmethylationOVT296S297S302T303S450proteinRNASCNVmethylationPDACT296S297S302T303S450proteinRNASCNVmethylationUCECT296S297S302T303S450proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
MAPKAPK2S4501.6e-132.8e-34.5e-50.0381.5e-30.0150.280.072.5e-3-0.956.2e-3
WNK1S4505.3e-120.880.0382.7e-40.0290.0450.0150.0770.0120.0170.008
CAMK1S4501.7e-100.0187.4e-30.266.5e-40.165.3e-48.3e-4-0.50.160.094
STK10S4502.6e-100.180.0140.0180.0416.9e-31.3e-30.180.380.0180.2
MAPK14S4506.9e-100.020.0340.250.0541.2e-30.0320.0580.320.621.3e-3
IKBKBS4501.2e-90.050.0880.260.0040.0460.181.6e-30.0170.430.057
NEK7S4502.8e-90.280.0812.9e-30.0931.6e-50.142.7e-3-0.150.0440.053
TBCKS4504.8e-90.0840.0360.0163.9e-30.120.085.4e-3-0.540.0130.16
BMP2KS4505.6e-90.490.0190.688.3e-40.020.0140.0320.0630.240.093
RIPK1S4501.5e-81.3e-32.5e-80.30.0469.9e-38.5e-30.97-0.930.820.48
Showing 1 to 10 of 2690 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PTP4A1S450-2.9e-8-0.17-0.34-2.2e-4-0.39-0.581-3.3e-4-0.024-1.5e-3-0.27
PLPP2S450-8.8e-8-0.71-0.031-2.6e-3--0.14-0.047-6.7e-4-0.22-0.55-0.074
HDHD5S450-2.1e-6-0.1-0.79-0.082-0.14-0.019-0.038-0.47-0.56-0.011-0.11
PTPRGS450-3.9e-5-0.56-2.7e-50.63-0.023-0.52-6.2e-30.92--0.64-0.043
PTPRFS450-4.1e-5-0.42-0.0050.72-0.79-1.0e-4-7.9e-3-0.270.63-0.37-0.16
PGAM5S450-8.2e-5-0.640.79-0.022-0.03-0.97-0.13-1.2e-4-0.85-0.052
TIMM50S450-1.0e-4-0.0429.2e-4-0.053-0.053-0.2-0.028-7.8e-3-0.27-0.33-0.13
PTPN3S297-1.8e-4-----0.027----0.02-0.053
PTPN3S450-2.6e-4-0.032-0.0220.32--0.12-0.0450.52-0.066-0.14-0.21
PTPRAS450-2.6e-4-0.61-8.7e-30.47-0.073-0.81-0.026-0.250.75-0.019-0.088
Showing 1 to 10 of 1200 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.