WNK2: WNK lysine deficient protein kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6elm chain A
6fbk chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S45 PQRFLRRS VVESDQE 4 172 - - - - - - 9 - 39 23 9 8 - - - - - - 71 13 S49 LRRSVVES DQEEPPG 6 90 - - 8 - - - - - 11 6 20 17 - - 8 1 3 2 11 3 S560 KEQQDVGS PDKARGP 7 483 - - - - - - 55 - 45 25 39 31 10 8 40 11 100 42 61 16 S1150 VTSGKELS DSCEGAF 8 573 - - 7 - - - 36 - 92 53 54 49 5 4 56 13 93 40 62 9 S1152 SGKELSDS CEGAFGG 2 61 - - - - - - - - - - - - - - - - 36 16 - 9 S1262 DKAEDMLS EDTDADR 4 90 - - - - - - 18 - - - 5 5 - - 7 2 - - 49 4 S1271 DTDADRGS DPGTSPP 3 65 - - - - - - 36 - - - - - - - 6 1 - - 11 11 T1275 DRGSDPGT SPPHLST 1 9 - - - - - - 9 - - - - - - - - - - - - - S1276 RGSDPGTS PPHLSTC 2 49 - - - - - - 31 - - - - - - - 15 3 - - - - S1608 HVPTSSAS AGTPVEV 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S45 PQRFLRRS VVESDQE -1.4e-3 - - - - -0.16 - - - - -1.8e-3 S49 LRRSVVES DQEEPPG 0.17 - - - - - 0.17 - - - - S560 KEQQDVGS PDKARGP -0.2 - - - - -0.2 4.6e-13 - -0.78 -2.5e-17 -0.92 S1150 VTSGKELS DSCEGAF -3.3e-7 - - - - -1.4e-8 1.7e-7 - -0.12 -2.5e-16 - S1152 SGKELSDS CEGAFGG -7.8e-13 - - - - - - - - -7.7e-13 - S1262 DKAEDMLS EDTDADR - - - - - - - - - - - S1271 DTDADRGS DPGTSPP - - - - - - - - - - - T1275 DRGSDPGT SPPHLST - - - - - - - - - - - S1276 RGSDPGTS PPHLSTC - - - - - - - - - - - S1608 HVPTSSAS AGTPVEV - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S45
S49
S560
S1150
S1152
S1262
S1271
T1275
S1276
S1608
T1611
S1632
S1680
S1686
S1765
S1777
S1798
S1805
S1817
S1818
S1843
S1844
S1846
S1862
S1885
S1889
T1894
S2009
S2056
S2067
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation CCRCC S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation COAD S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation GBM S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation HNSCC S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation LSCC S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation LUAD S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation OV S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation PDAC S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation UCEC S45 S49 S560 S1150 S1152 S1262 S1271 T1275 S1276 S1608 T1611 S1632 S1680 S1686 S1765 S1777 S1798 S1805 S1817 S1818 S1843 S1844 S1846 S1862 S1885 S1889 T1894 S2009 S2056 S2067 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S45
S49
S560
S1150
S1152
S1262
S1271
T1275
S1276
S1608
T1611
S1632
S1680
S1686
S1765
S1777
S1798
S1805
S1817
S1818
S1843
S1844
S1846
S1862
S1885
S1889
T1894
S2009
S2056
S2067
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S45
S49
S560
S1150
S1152
S1262
S1271
T1275
S1276
S1608
T1611
S1632
S1680
S1686
S1765
S1777
S1798
S1805
S1817
S1818
S1843
S1844
S1846
S1862
S1885
S1889
T1894
S2009
S2056
S2067
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.