Protein: ENSP00000301067
Gene: KMT2D

LinkedOmicsKB © 2022-2023 Zhang Lab

KMT2D:
lysine methyltransferase 2D

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S42NPHVGEVSVLSSGSP219----27----------73--
S45VGEVSVLSSGSPRLQ540----63--534445--51--
S46GEVSVLSSGSPRLQE19----72--------------
S48VSVLSSGSPRLQETP7345----162071-1810109--40423119518
S186GASIPCRSPGCPRLY3128----------554743----262
T366RSVAEQHTPVCSRFS619417-98------2927445512--209
S373TPVCSRFSPPEPGDT101275122-5855727290-108629890110101471165247218
T380SPPEPGDTPTDEPDA4128--1211--------1616--325216
T382PEPGDTPTDEPDALY215----------55----32--
Y389TDEPDALYVACQGQP18--44----------------
Showing 1 to 10 of 109 rows
102550100
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S42NPHVGEVSVLSSGSP-----------
S45VGEVSVLSSGSPRLQ-----------
S46GEVSVLSSGSPRLQE-----------
S48VSVLSSGSPRLQETP-0.4---------2.6e-30.069
S186GASIPCRSPGCPRLY1.6e-3------1.6e-3---
T366RSVAEQHTPVCSRFS0.16------0.059-9.6e-5--
S373TPVCSRFSPPEPGDT-0.21--0.41.7e-4--8.2e-90.0290.013-0.48-1.0e-4-0.43
T380SPPEPGDTPTDEPDA-0.49----------0.49
T382PEPGDTPTDEPDALY-----------
Y389TDEPDALYVACQGQP-----------
Showing 1 to 10 of 109 rows
102550100
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

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

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.