USP8: ubiquitin specific peptidase 8
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1whb chain A
2a9u chain A
2a9u chain B
2gfo chain A
2gwf chain A
2gwf chain C
2gwf chain E
3n3k chain A
6f09 chain A
6f09 chain B
6f09 chain C
6f09 chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S16 KELYLSSS LKDLNKK 2 23 - - - - - - 18 - - - - - - - - - - - 5 - T141 LQQKRQET GREDGGT 1 9 - - - - - - 9 - - - - - - - - - - - - - S153 GGTLAKGS LENVLDS 10 566 8 - 4 4 5 4 80 - 78 46 84 78 4 4 5 3 47 15 79 18 T351 PSKPAAQT PPASIEV 4 45 - - - - - - - - 6 4 5 4 9 8 - - - - 7 2 T379 MGPLNIST PVEPVAA 8 311 22 - 21 20 - - - - 6 3 19 17 44 40 7 1 3 2 90 16 S392 AASKSDVS PIIQPVP 10 1117 90 - 58 52 34 29 90 - 91 54 59 56 82 76 73 17 100 43 95 18 S400 PIIQPVPS IKNVPQI 4 100 - - 28 27 - - 19 - - - 5 4 - - - - - - 13 4 S425 PEEHRIKS ESTNHEQ 1 9 - - - - - - - - - - - - - - - - 7 2 - - S434 STNHEQQS PQSGKVI 7 226 8 - - - 3 6 99 - 6 3 9 9 - - 44 11 - - 24 4 S437 HEQQSPQS GKVIPDR 1 9 - - - - - - 9 - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S16 KELYLSSS LKDLNKK - - - - - - - - - - - T141 LQQKRQET GREDGGT - - - - - - - - - - - S153 GGTLAKGS LENVLDS 1.2e-6 - - - - -0.81 7.5e-26 - - -0.076 0.23 T351 PSKPAAQT PPASIEV - - - - - - - - - - - T379 MGPLNIST PVEPVAA 0.066 - 0.026 - - - - 0.12 - - -0.56 S392 AASKSDVS PIIQPVP 0.59 - 1.2e-3 0.014 - -1.6e-4 0.63 0.2 -5.3e-4 -0.013 1.8e-4 S400 PIIQPVPS IKNVPQI 0.14 - 0.14 - - - - - - - - S425 PEEHRIKS ESTNHEQ - - - - - - - - - - - S434 STNHEQQS PQSGKVI 3.1e-3 - - - - - - - 3.1e-3 - - S437 HEQQSPQS GKVIPDR - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S16
T141
S153
T351
T379
S392
S400
S425
S434
S437
S452
T454
S555
S557
T577
T618
S641
S691
T692
S716
S718
S719
T723
T737
S772
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation CCRCC S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation COAD S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation GBM S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation HNSCC S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation LSCC S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation LUAD S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation OV S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation PDAC S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation UCEC S16 T141 S153 T351 T379 S392 S400 S425 S434 S437 S452 T454 S555 S557 T577 T618 S641 S691 T692 S716 S718 S719 T723 T737 S772 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S16
T141
S153
T351
T379
S392
S400
S425
S434
S437
S452
T454
S555
S557
T577
T618
S641
S691
T692
S716
S718
S719
T723
T737
S772
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S16
T141
S153
T351
T379
S392
S400
S425
S434
S437
S452
T454
S555
S557
T577
T618
S641
S691
T692
S716
S718
S719
T723
T737
S772
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.