MAP2K1: mitogen-activated protein kinase kinase 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1s9j chain A
2p55 chain A
3dv3 chain A
3dy7 chain A
3e8n chain A
3eqb chain A
3eqc chain A
3eqd chain A
3eqf chain A
3eqg chain A
3eqh chain A
3eqi chain A
3mbl chain A
3orn chain A
3os3 chain A
3pp1 chain A
3sls chain A
3sls chain B
3v01 chain A
3v04 chain A
3vvh chain A
3vvh chain B
3vvh chain C
3w8q chain A
3wig chain A
3zls chain A
3zlw chain A
3zlx chain A
3zly chain A
3zm4 chain A
4an2 chain A
4an3 chain A
4an9 chain A
4anb chain A
4ark chain A
4lmn chain A
4mne chain A
4mne chain D
4mne chain E
4mne chain H
4u7z chain A
4u80 chain A
4u81 chain A
5bx0 chain A
5eym chain A
5eym chain B
5hze chain A
5yt3 chain A
5yt3 chain B
5yt3 chain C
5yt3 chain D
6nyb chain B
6pp9 chain B
6q0j chain C
6q0j chain D
6q0t chain C
6u2g chain A
6v2w chain B
6x2p chain D
6x2s chain D
6x2x chain D
7b3m chain A
7b3m chain B
7b7r chain A
7b7r chain B
7b94 chain A
7b94 chain B
7b9l chain A
7b9l chain B
7m0t chain B
7m0u chain B
7m0v chain B
7m0w chain B
7m0x chain B
7m0y chain B
7m0z chain B
7mfd chain B
7pqv chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T7 _MPKKKPT PIQLNPA 7 318 23 - - - - - 9 - 23 13 29 29 70 66 - - 21 10 14 11 S18 LNPAPDGS AVNGTSS 2 26 9 - 9 8 - - - - - - - - - - - - - - - - T23 DGSAVNGT SSAETNL 2 37 - - 15 14 - - - - - - - - - - - - 6 2 - - S25 SAVNGTSS AETNLEA 1 9 - - 5 4 - - - - - - - - - - - - - - - - S72 DDDFEKIS ELGAGNG 2 25 - - 4 4 - - - - - - - - - - - - - - 13 4 S231 VGTRSYMS PERLQGT 1 8 - - - - - - 8 - - - - - - - - - - - - - T286 VEGDAAET PPRPRTP 6 329 46 - 12 2 - - 27 - 69 38 58 52 13 12 - - - - - - T292 ETPPRPRT PGRPLSS 6 525 - - 13 10 - - 99 - 95 56 57 51 71 64 8 1 - - - - S298 RTPGRPLS SYGMDSR 1 37 - - - - - - 37 - - - - - - - - - - - - - S299 TPGRPLSS YGMDSRP 4 85 - - 17 15 - - 26 - 5 3 10 9 - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T7 _MPKKKPT PIQLNPA 3.3e-18 - - - - 0.011 9.2e-8 2.1e-10 - 1.6e-3 - S18 LNPAPDGS AVNGTSS - - - - - - - - - - - T23 DGSAVNGT SSAETNL - - - - - - - - - - - S25 SAVNGTSS AETNLEA - - - - - - - - - - - S72 DDDFEKIS ELGAGNG - - - - - - - - - - - S231 VGTRSYMS PERLQGT - - - - - - - - - - - T286 VEGDAAET PPRPRTP 6.6e-5 - - - - 8.6e-3 2.6e-3 - - - - T292 ETPPRPRT PGRPLSS -8.9e-6 - - - - -3.2e-8 -0.13 -0.52 - - - S298 RTPGRPLS SYGMDSR - - - - - - - - - - - S299 TPGRPLSS YGMDSRP - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T7
S18
T23
S25
S72
S231
T286
T292
S298
S299
Y300
S304
Y316
S327
S385
T386
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation CCRCC T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation COAD T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation GBM T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation HNSCC T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation LSCC T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation LUAD T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation OV T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation PDAC T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation UCEC T7 S18 T23 S25 S72 S231 T286 T292 S298 S299 Y300 S304 Y316 S327 S385 T386 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T7
S18
T23
S25
S72
S231
T286
T292
S298
S299
Y300
S304
Y316
S327
S385
T386
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T7
S18
T23
S25
S72
S231
T286
T292
S298
S299
Y300
S304
Y316
S327
S385
T386
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.