PCSK9: proprotein convertase subtilisin/kexin type 9
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2p4e chain A
2p4e chain P
2pmw chain A
2pmw chain B
2qtw chain A
2qtw chain B
2w2m chain A
2w2m chain P
2w2n chain A
2w2n chain P
2w2o chain A
2w2o chain P
2w2p chain A
2w2p chain P
2w2q chain A
2w2q chain P
2xtj chain A
2xtj chain P
3bps chain A
3bps chain P
3gcw chain A
3gcw chain P
3gcx chain A
3gcx chain P
3h42 chain A
3h42 chain B
3m0c chain A
3m0c chain B
3p5b chain A
3p5b chain P
3p5c chain A
3p5c chain P
3sqo chain A
3sqo chain P
4k8r chain A
4k8r chain B
4ne9 chain A
4ne9 chain B
4ne9 chain C
4ne9 chain P
4nmx chain A
4nmx chain B
4ov6 chain A
4ov6 chain B
4ov6 chain D
4ov6 chain E
5oca chain A
5oca chain B
5vl7 chain A
5vl7 chain B
5vla chain A
5vlh chain A
5vlk chain A
5vll chain A
5vlp chain A
6e4y chain P
6e4z chain P
6mv5 chain P
6olz chain A
6om0 chain y
6om7 chain y
6u26 chain A
6u26 chain B
6u2f chain A
6u2n chain A
6u2n chain B
6u2p chain A
6u2p chain B
6u36 chain A
6u36 chain B
6u38 chain A
6u38 chain B
6u3i chain A
6u3x chain A
6u3x chain B
6xib chain A
6xib chain B
6xic chain A
6xic chain B
6xid chain A
6xid chain B
6xie chain A
6xie chain B
6xif chain A
6xif chain B
7anq chain A
7kev chain A
7kev chain B
7kfa chain A
7kfa chain B
7s5g chain A
7s5g chain B
7s5h chain A
7s5h chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S47 ELVLALRS EEDGLAE 1 27 - - - - - - - - - - - - - - 22 5 - - - - S688 SRHLAQAS QELQ___ 10 1330 116 - 87 64 78 83 90 - 56 32 108 99 106 97 76 18 92 40 70 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S47 ELVLALRS EEDGLAE - - - - - - - - - - - S688 SRHLAQAS QELQ___ -2.5e-13 - -8.8e-6 0.8 - -0.15 -1.7e-10 -4.1e-17 -1.4e-3 0.012 0.67
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S47
S688
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S47 S688 protein RNA SCNV methylation CCRCC S47 S688 protein RNA SCNV methylation COAD S47 S688 protein RNA SCNV methylation GBM S47 S688 protein RNA SCNV methylation HNSCC S47 S688 protein RNA SCNV methylation LSCC S47 S688 protein RNA SCNV methylation LUAD S47 S688 protein RNA SCNV methylation OV S47 S688 protein RNA SCNV methylation PDAC S47 S688 protein RNA SCNV methylation UCEC S47 S688 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S47
S688
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S47
S688
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.