IRS1: insulin receptor substrate 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1irs chain A
1k3a chain B
1qqg chain A
1qqg chain B
2z8c chain B
5u1m chain A
6bnt chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S270 EFRPRSKS QSSSNCS 9 783 8 - - - 53 54 62 - 56 35 74 67 44 41 33 10 93 40 95 18 S272 RPRSKSQS SSNCSNP 4 30 6 - - - 7 2 - - - - - - 5 4 - - - - 6 - S273 PRSKSQSS SNCSNPI 2 12 6 - - - - - - - - - - - - - - - - - 6 - S274 RSKSQSSS NCSNPIS 1 9 - - - - - - - - - - - - 5 4 - - - - - - S303 QVGLTRRS RTESITA 5 153 - - - - - - - - 5 4 5 4 - - 7 2 28 10 70 18 T305 GLTRRSRT ESITATS 2 18 - - - - 4 5 - - - - - - - - 7 2 - - - - S307 TRRSRTES ITATSPA 7 254 7 - 4 4 - - - - 5 3 - - 44 40 36 7 41 18 43 2 T309 RSRTESIT ATSPASM 2 9 - - - - - - - - - - - - - - - - 4 1 4 - T311 RTESITAT SPASMVG 2 30 22 - - - - - - - - - - - 4 4 - - - - - - S312 TESITATS PASMVGG 7 205 - - - - 4 5 9 - - - 10 9 10 8 71 15 17 9 33 5
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S270 EFRPRSKS QSSSNCS -8.7e-4 - - -8.2e-7 - 3.5e-3 -2.7e-3 -9.6e-5 -0.33 4.5e-8 -1.1e-5 S272 RPRSKSQS SSNCSNP - - - - - - - - - - - S273 PRSKSQSS SNCSNPI - - - - - - - - - - - S274 RSKSQSSS NCSNPIS - - - - - - - - - - - S303 QVGLTRRS RTESITA -1.4e-3 - - - - - - - - -0.26 -7.3e-4 T305 GLTRRSRT ESITATS - - - - - - - - - - - S307 TRRSRTES ITATSPA -0.81 - - - - - - -0.56 - 0.81 - T309 RSRTESIT ATSPASM - - - - - - - - - - - T311 RTESITAT SPASMVG - - - - - - - - - - - S312 TESITATS PASMVGG -0.064 - - - - - - - -0.064 - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S270
S272
S273
S274
S303
T305
S307
T309
T311
S312
S315
S323
S329
S330
T335
S337
S341
S345
S348
S374
S383
S388
S391
S393
S402
S412
S413
S417
S419
S421
S434
T446
S449
T453
S463
Y465
S503
S513
S527
T530
S531
S541
S544
S547
S574
S581
Y582
S629
Y632
S636
S641
Y662
S668
S672
S736
S741
S745
S766
S792
S794
S862
S892
S925
S1005
S1043
S1078
S1100
S1101
T1103
S1131
S1132
S1133
S1134
S1135
S1142
S1143
S1145
S1222
S1223
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation CCRCC S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation COAD S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation GBM S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation HNSCC S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation LSCC S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation LUAD S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation OV S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation PDAC S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation UCEC S270 S272 S273 S274 S303 T305 S307 T309 T311 S312 S315 S323 S329 S330 T335 S337 S341 S345 S348 S374 S383 S388 S391 S393 S402 S412 S413 S417 S419 S421 S434 T446 S449 T453 S463 Y465 S503 S513 S527 T530 S531 S541 S544 S547 S574 S581 Y582 S629 Y632 S636 S641 Y662 S668 S672 S736 S741 S745 S766 S792 S794 S862 S892 S925 S1005 S1043 S1078 S1100 S1101 T1103 S1131 S1132 S1133 S1134 S1135 S1142 S1143 S1145 S1222 S1223 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S270
S272
S273
S274
S303
T305
S307
T309
T311
S312
S315
S323
S329
S330
T335
S337
S341
S345
S348
S374
S383
S388
S391
S393
S402
S412
S413
S417
S419
S421
S434
T446
S449
T453
S463
Y465
S503
S513
S527
T530
S531
S541
S544
S547
S574
S581
Y582
S629
Y632
S636
S641
Y662
S668
S672
S736
S741
S745
S766
S792
S794
S862
S892
S925
S1005
S1043
S1078
S1100
S1101
T1103
S1131
S1132
S1133
S1134
S1135
S1142
S1143
S1145
S1222
S1223
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S270
S272
S273
S274
S303
T305
S307
T309
T311
S312
S315
S323
S329
S330
T335
S337
S341
S345
S348
S374
S383
S388
S391
S393
S402
S412
S413
S417
S419
S421
S434
T446
S449
T453
S463
Y465
S503
S513
S527
T530
S531
S541
S544
S547
S574
S581
Y582
S629
Y632
S636
S641
Y662
S668
S672
S736
S741
S745
S766
S792
S794
S862
S892
S925
S1005
S1043
S1078
S1100
S1101
T1103
S1131
S1132
S1133
S1134
S1135
S1142
S1143
S1145
S1222
S1223
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.