Protein: ENSP00000305721
Gene: IBTK

LinkedOmicsKB © 2022-2023 Zhang Lab

IBTK:
inhibitor of Bruton tyrosine kinase

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S990KKKPRKRSDSSGGYN811925---1089---5418176242-9
S992KPRKRSDSSGGYNLS1066448-242478749-54284540433912273312416
S993PRKRSDSSGGYNLSD815235-44--18-2213191844--515-
Y996RSDSSGGYNLSDIIQ932716-2010202473-171225231412--351493
S999SSGGYNLSDIIQSPS32914-43----53----------
S1004NLSDIIQSPSSTGLL961179-4838111546---746836307138198318
S1018LKSGKTNSVESLPEL951987-413145--442549465754811043518
S1021GKTNSVESLPELLTS8522105-33243644--24141097569--492253
T1027ESLPELLTSDSEGSY214--44------------51--
S1028SLPELLTSDSEGSYA18------------------62
Showing 1 to 10 of 21 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S990KKKPRKRSDSSGGYN-----------
S992KPRKRSDSSGGYNLS0.27-1.4e-7-5.2e-3--0.0220.261.4e-4-0.9-0.02
S993PRKRSDSSGGYNLSD-0.93-----0.93-----
Y996RSDSSGGYNLSDIIQ2.5e-4-1.3e-39.2e-4---0.25--0.049-
S999SSGGYNLSDIIQSPS-----------
S1004NLSDIIQSPSSTGLL0.2-0.11----0.714.5e-6--2.9e-50.21
S1018LKSGKTNSVESLPEL-2.8e-3--0.97---0.058-0.034-2.1e-3--0.65
S1021GKTNSVESLPELLTS-3.0e-6-0.29-1.4e-7--0.39--2.3e-4--0.09-
T1027ESLPELLTSDSEGSY-----------
S1028SLPELLTSDSEGSYA-----------
Showing 1 to 10 of 21 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationCCRCCS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationCOADS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationGBMS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationHNSCCS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationLSCCS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationLUADS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationOVS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationPDACS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylationUCECS990S992S993Y996S999S1004S1018S1021T1027S1028S1030S1039S1045T1049T1068S1069S1083S1111S1113S1116S1203proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.