Protein: ENSP00000305976
Gene: SIK2

LinkedOmicsKB © 2022-2023 Zhang Lab

SIK2:
salt inducible kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S343RLKSHRSSFPVEQRL10110763-6544889190-70399386444055129237899
S358DGRQRRPSTIAEQTV107919-3017595790-523040351312831910544897
T359GRQRRPSTIAEQTVA3259---------4444------
T376QTVGLPVTMHSPNMR11717-------------------
S379GLPVTMHSPNMRLLR83189---4581---1010131154141167416
S442LVRKGCQSLPSNMME242--44------1915--------
S445KGCQSLPSNMMETSI225--16-------54--------
S451PSNMMETSIDEGLET19------9-------------
T458SIDEGLETEGEAEED19--------72----------
T484RSGQRRHTLSEVTNQ101132113-7362333999-905298901019371103432312
Showing 1 to 10 of 20 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S343RLKSHRSSFPVEQRL-1.9e-6--3.5e-4-0.079-2.3e-3-5.1e-20-7.1e-3-2.3e-34.4e-6-
S358DGRQRRPSTIAEQTV-0.046--0.59-0.028-0.15-8.9e-3--0.0220.18-
T359GRQRRPSTIAEQTVA-----------
T376QTVGLPVTMHSPNMR-----------
S379GLPVTMHSPNMRLLR0.59-------0.87-0.54
S442LVRKGCQSLPSNMME-----------
S445KGCQSLPSNMMETSI-----------
S451PSNMMETSIDEGLET-----------
T458SIDEGLETEGEAEED-----------
T484RSGQRRHTLSEVTNQ-4e-13-6e-15-9.8e-7--1e-13-3.9e-15-0.7--2.9e-3-5.7e-4
Showing 1 to 10 of 20 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationCCRCCS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationCOADS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationGBMS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationHNSCCS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationLSCCS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationLUADS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationOVS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationPDACS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylationUCECS343S358T359T376S379S442S445S451T458T484S486S509S512S515S521S534S545S576S587S674proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.