EIF2AK3: eukaryotic translation initiation factor 2 alpha kinase 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4g31 chain A
4g34 chain A
4m7i chain A
4x7h chain A
4x7j chain A
4x7k chain A
4x7l chain A
4x7n chain A
4x7o chain A
4yzs chain A
4yzs chain B
5sv7 chain A
5sv7 chain B
5sv7 chain C
5sv7 chain D
7mf0 chain AAA
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S555 PHRQRKES ETQCQTE 10 484 8 - 13 4 27 18 53 - 41 23 19 19 8 8 42 9 82 34 67 9 T557 RQRKESET QCQTENK 6 178 6 - - - 8 10 - - 5 3 64 59 9 8 - - - - 6 - T561 ESETQCQT ENKYDSV 2 19 - - - - - - 9 - - - 5 5 - - - - - - - - Y565 QCQTENKY DSVSGEA 1 17 17 - - - - - - - - - - - - - - - - - - - S567 QTENKYDS VSGEAND 1 8 8 - - - - - - - - - - - - - - - - - - - S575 VSGEANDS SWNDIKN 1 9 - - - - - - - - - - - - 5 4 - - - - - - S576 SGEANDSS WNDIKNS 1 48 - - - - - - - - - - - - - - - - - - 48 - S679 EIWLKDES TDWPLSS 2 44 - - - - - - - - - - 5 4 - - - - - - 31 4 T680 IWLKDEST DWPLSSP 2 17 - - - - - - - - - - - - 5 4 - - - - 5 3 S685 ESTDWPLS SPSPMDA 2 50 - - - - - - - - - - - - 9 8 - - - - 26 7
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S555 PHRQRKES ETQCQTE -0.037 - - 0.16 - -0.97 - - - -6.3e-7 - T557 RQRKESET QCQTENK 2.3e-15 - - - - - 2.4e-15 - - - - T561 ESETQCQT ENKYDSV - - - - - - - - - - - Y565 QCQTENKY DSVSGEA - - - - - - - - - - - S567 QTENKYDS VSGEAND - - - - - - - - - - - S575 VSGEANDS SWNDIKN - - - - - - - - - - - S576 SGEANDSS WNDIKNS - - - - - - - - - - - S679 EIWLKDES TDWPLSS - - - - - - - - - - - T680 IWLKDEST DWPLSSP - - - - - - - - - - - S685 ESTDWPLS SPSPMDA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S555
T557
T561
Y565
S567
S575
S576
S679
T680
S685
S686
S688
S694
T705
S715
S805
S811
S817
S844
S845
S849
S854
S856
S879
T970
T973
T982
S1092
S1094
S1096
S1098
S1111
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation CCRCC S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation COAD S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation GBM S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation HNSCC S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation LSCC S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation LUAD S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation OV S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation PDAC S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation UCEC S555 T557 T561 Y565 S567 S575 S576 S679 T680 S685 S686 S688 S694 T705 S715 S805 S811 S817 S844 S845 S849 S854 S856 S879 T970 T973 T982 S1092 S1094 S1096 S1098 S1111 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S555
T557
T561
Y565
S567
S575
S576
S679
T680
S685
S686
S688
S694
T705
S715
S805
S811
S817
S844
S845
S849
S854
S856
S879
T970
T973
T982
S1092
S1094
S1096
S1098
S1111
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S555
T557
T561
Y565
S567
S575
S576
S679
T680
S685
S686
S688
S694
T705
S715
S805
S811
S817
S844
S845
S849
S854
S856
S879
T970
T973
T982
S1092
S1094
S1096
S1098
S1111
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.