RPTOR: regulatory associated protein of MTOR complex 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5h64 chain B
5h64 chain b
6bcu chain W
6bcu chain Y
6bcx chain W
6bcx chain Y
6sb0 chain N
6sb0 chain Y
6sb2 chain N
6sb2 chain Y
6u62 chain A
7owg chain Y
7pea chain E
7pea chain F
7peb chain E
7pec chain E
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S136 EVKKLCTS LRRNAKE 1 9 - - - - - - 9 - - - - - - - - - - - - - S696 EKNYALPS PATTEGG 9 727 31 - 62 48 - - 63 - 33 21 78 71 80 72 30 4 32 13 78 11 T699 YALPSPAT TEGGSLT 6 105 15 - 9 8 - - - - - - 10 9 9 7 - - 10 5 23 - T700 ALPSPATT EGGSLTP 5 80 - - - - - - - - - - 10 9 9 8 6 2 7 3 24 2 S704 PATTEGGS LTPVRDS 6 68 - - - - - - 9 - - - 10 9 5 4 15 2 6 2 6 - T706 TTEGGSLT PVRDSPC 8 341 - - 4 4 - - 46 - 18 10 4 4 10 8 42 10 52 22 89 18 S711 SLTPVRDS PCTPRLR 3 52 - - - - - - 9 - - - - - - - 12 3 - - 26 2 T714 PVRDSPCT PRLRSVS 5 120 - - - - - - 9 - - - 20 18 14 12 33 8 - - 6 - S719 PCTPRLRS VSSYGNI 10 695 42 - 30 28 20 16 45 - 64 34 68 62 70 64 27 7 39 16 47 16 S721 TPRLRSVS SYGNIRA 9 351 14 - 21 12 - - 18 - 55 32 59 55 17 17 27 7 8 3 6 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S136 EVKKLCTS LRRNAKE - - - - - - - - - - - S696 EKNYALPS PATTEGG -2.2e-10 - 0.8 - - -2.2e-5 -2.9e-8 -6.9e-11 - -0.31 0.13 T699 YALPSPAT TEGGSLT - - - - - - - - - - - T700 ALPSPATT EGGSLTP - - - - - - - - - - - S704 PATTEGGS LTPVRDS - - - - - - - - - - - T706 TTEGGSLT PVRDSPC -0.097 - - - - - - - -0.9 -3.0e-4 0.39 S711 SLTPVRDS PCTPRLR - - - - - - - - - - - T714 PVRDSPCT PRLRSVS 0.019 - - - - - 0.019 - - - - S719 PCTPRLRS VSSYGNI 0.2 - 0.015 -0.21 - -0.48 -0.001 0.72 - 6.2e-7 0.39 S721 TPRLRSVS SYGNIRA -2.8e-4 - 5.1e-6 - - -2.9e-3 -3.4e-15 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S136
S696
T699
T700
S704
T706
S711
T714
S719
S721
S722
S791
S792
S855
T857
S859
S863
T865
S877
S881
S882
T883
S884
S886
S887
T889
Y1059
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation CCRCC S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation COAD S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation GBM S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation HNSCC S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation LSCC S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation LUAD S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation OV S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation PDAC S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation UCEC S136 S696 T699 T700 S704 T706 S711 T714 S719 S721 S722 S791 S792 S855 T857 S859 S863 T865 S877 S881 S882 T883 S884 S886 S887 T889 Y1059 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S136
S696
T699
T700
S704
T706
S711
T714
S719
S721
S722
S791
S792
S855
T857
S859
S863
T865
S877
S881
S882
T883
S884
S886
S887
T889
Y1059
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S136
S696
T699
T700
S704
T706
S711
T714
S719
S721
S722
S791
S792
S855
T857
S859
S863
T865
S877
S881
S882
T883
S884
S886
S887
T889
Y1059
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.