Protein: ENSP00000307369
Gene: SHE

LinkedOmicsKB © 2022-2023 Zhang Lab

SHE:
Src homology 2 domain containing E

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

Loading, please wait
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S69GGKLRKNSEAGGAGP10105983-997881071-3220108991059762105447418
S85PGKGRKNSAAELGSG1071852-5458769-74434945545011105446816
S104GPKDSRLSRDSLQGL460--87------151554----6-
S107DSRLSRDSLQGLIQA74906-7859--9---89817670--7312-
S123AGKGRKNSRATEEEP61158-88--17---252444----512
Y204TVIILEDYADPYDAK19----------54--------
S246TEIRRRGSKDPLVKA425534---2123----30286257------
S259KALQLLDSPCEPADG3132--2422------554036------
S341EQIVRALSVQFEGAE882634-5131--27-9656108991101011436630--
S376KILKPALSDHSEGEK41518-44------35333532------
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

Loading, please wait
Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S69GGKLRKNSEAGGAGP-1.3e-50-0.53---1.9e-10-8.7e-35-2.4e-21--1.2e-12-0.044
S85PGKGRKNSAAELGSG-5.6e-50---9.6e-15--1.3e-17-2.9e-21--0.04-2.2e-8-2.7e-3
S104GPKDSRLSRDSLQGL-----------
S107DSRLSRDSLQGLIQA-3.1e-35--9.6e-3----7.5e-28-2.3e-15---
S123AGKGRKNSRATEEEP-3.8e-9------3.8e-9----
Y204TVIILEDYADPYDAK-----------
S246TEIRRRGSKDPLVKA-2.6e-41---9.1e-10---2.1e-15-2.2e-20---
S259KALQLLDSPCEPADG-1.3e-3-0.43-----8.9e-8---
S341EQIVRALSVQFEGAE-2.4e-34--0.65---6.1e-15-2.1e-34-2.5e-21-8.2e-3-
S376KILKPALSDHSEGEK-1.4e-28------1e-17-1.1e-12---
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

Loading, please wait
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationCCRCCS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationCOADS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationGBMS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationHNSCCS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationLSCCS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationLUADS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationOVS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationPDACS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylationUCECS69S85S104S107S123Y204S246S259S341S376S422proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

Loading, please wait
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

Loading, please wait
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.