BTK: Bruton tyrosine kinase
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1aww chain A
1awx chain A
1b55 chain A
1b55 chain B
1btk chain A
1btk chain B
1bwn chain A
1bwn chain B
1k2p chain A
1k2p chain B
1qly chain A
2ge9 chain A
2z0p chain A
2z0p chain B
2z0p chain C
2z0p chain D
3gen chain A
3k54 chain A
3ocs chain A
3oct chain A
3p08 chain A
3p08 chain B
3pix chain A
3piy chain A
3piz chain A
3pj1 chain A
3pj2 chain A
3pj3 chain A
4nwm chain A
4nwm chain B
4ot5 chain A
4ot6 chain A
4otf chain A
4otq chain A
4otr chain A
4rfy chain A
4rfz chain A
4rg0 chain A
4rx5 chain A
4yhf chain A
4yhf chain B
4z3v chain A
4zly chain A
4zlz chain A
5bpy chain A
5bpy chain B
5bq0 chain A
5fbn chain C
5fbn chain D
5fbo chain A
5j87 chain A
5j87 chain B
5j87 chain C
5j87 chain D
5jrs chain A
5jrs chain B
5kup chain A
5p9f chain A
5p9g chain A
5p9h chain A
5p9i chain A
5p9j chain A
5p9k chain A
5p9l chain A
5p9m chain A
5t18 chain A
5u9d chain A
5vfi chain A
5vgo chain A
5xyz chain A
5xyz chain B
5zz4 chain A
5zz4 chain B
5zz4 chain C
5zz4 chain D
5zz4 chain E
5zz4 chain F
6aua chain A
6aub chain A
6bik chain A
6bke chain A
6bkh chain A
6bkw chain A
6bln chain A
6di0 chain A
6di1 chain A
6di3 chain A
6di5 chain A
6di9 chain A
6e4f chain A
6ep9 chain A
6hrp chain A
6hrt chain A
6htf chain A
6j6m chain A
6n9p chain A
6nfh chain A
6nfi chain A
6nzm chain A
6nzm chain D
6o8i chain A
6omu chain A
6s90 chain A
6s90 chain B
6tfp chain A
6tfp chain B
6tfp chain C
6tfp chain D
6tfp chain E
6tse chain A
6tse chain B
6tt2 chain A
6tt2 chain B
6tuh chain A
6tuh chain B
6tuh chain C
6tuh chain D
6tvn chain A
6tvn chain B
6tvn chain C
6tvn chain D
6vxq chain A
6w06 chain A
6w07 chain A
6w7o chain A
6w7o chain B
6w8i chain A
6w8i chain B
6w8i chain C
6x3n chain A
6x3o chain A
6x3o chain B
6x3p chain A
6xe4 chain A
6yyf chain A
6yyf chain B
6yyg chain A
6yyg chain B
6yyg chain C
6yyg chain D
6yyk chain A
6yyk chain B
7kxl chain A
7kxm chain A
7kxn chain A
7kxo chain A
7kxp chain A
7kxq chain A
7l5o chain A
7l5p chain A
7l5p chain B
7lty chain A
7ltz chain A
7n4q chain A
7n4r chain A
7n4s chain A
7n5o chain A
7n5r chain A
7n5x chain A
7n5y chain A
7r60 chain A
7r61 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S55 RRGSKKGS IDVEKIT 9 771 59 - 8 - 18 18 45 - 43 26 103 94 101 92 - - 89 39 29 7 S174 ILENRNGS LKPGSSH 4 131 - - - - - - 53 - - - 25 22 - - 7 2 15 7 - - S179 NGSLKPGS SHRKTKK 4 178 - - 63 44 - - 9 - - - - - 26 23 - - 10 3 - - S180 GSLKPGSS HRKTKKP 6 338 59 - 13 4 - - - - - - 50 45 59 51 6 2 35 14 - - T191 TKKPLPPT PEEDQIL 9 481 27 - 4 4 - - 36 - 46 28 68 63 59 53 6 2 59 22 4 - Y223 LKKVVALY DYMPMNA 2 13 - - - - - - - - - - - - 4 4 3 2 - - - - S604 PYERFTNS ETAEHIA 2 43 - - - - - - - - - - 9 9 13 12 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S55 RRGSKKGS IDVEKIT 0.95 - - - - 6.2e-4 -9.0e-4 -5.8e-4 - 5.2e-4 - S174 ILENRNGS LKPGSSH 0.78 - - - - - 0.78 - - - - S179 NGSLKPGS SHRKTKK 2.1e-6 - 3e-12 - - - - -0.79 - - - S180 GSLKPGSS HRKTKKP -0.015 - - - - - -3.7e-5 -0.25 - 0.29 - T191 TKKPLPPT PEEDQIL -1.4e-9 - - - - 0.25 -2.2e-11 -4.1e-14 - 0.33 - Y223 LKKVVALY DYMPMNA - - - - - - - - - - - S604 PYERFTNS ETAEHIA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S55
S174
S179
S180
T191
Y223
S604
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation CCRCC S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation COAD S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation GBM S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation HNSCC S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation LSCC S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation LUAD S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation OV S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation PDAC S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation UCEC S55 S174 S179 S180 T191 Y223 S604 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S55
S174
S179
S180
T191
Y223
S604
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S55
S174
S179
S180
T191
Y223
S604
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.