LEMD3: LEM domain containing 3
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2ch0 chain A
5zoj chain D
5zoj chain E
5zok chain B
5zok chain D
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S7 _MAAAAAS APQQLSD 1 26 - - - - - - - - - - - - 14 12 - - - - - - S13 ASAPQQLS DEELFSQ 1 26 - - - - - - - - - - - - 14 12 - - - - - - S19 LSDEELFS QLRRYGL 1 26 - - - - - - - - - - - - 14 12 - - - - - - S27 QLRRYGLS PGPVTES 6 272 22 - - - - - 18 - 80 47 10 9 28 24 28 6 - - - - S95 GMGVRPVS GDLSYLR 3 68 - - - - - - - - 10 7 14 13 - - 18 6 - - - - T103 GDLSYLRT PGGLCRI 1 17 - - - - - - - - - - - - - - 15 2 - - - - S111 PGGLCRIS ASGPESL 5 220 - - - - - - - - 20 9 49 47 18 15 - - 13 5 33 11 S113 GLCRISAS GPESLLG 2 26 - - - - - - - - 5 4 9 8 - - - - - - - - S140 SKVLLGFS SDESDVE 6 167 - - 4 4 - - 18 - 46 28 19 17 9 8 - - - - 11 3 S141 KVLLGFSS DESDVEA 7 107 8 - 4 4 - - - - 15 11 5 5 5 4 25 7 - - 11 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S7 _MAAAAAS APQQLSD - - - - - - - - - - - S13 ASAPQQLS DEELFSQ - - - - - - - - - - - S19 LSDEELFS QLRRYGL - - - - - - - - - - - S27 QLRRYGLS PGPVTES 1e-9 - - - - 4.4e-8 - 1.6e-3 - - - S95 GMGVRPVS GDLSYLR - - - - - - - - - - - T103 GDLSYLRT PGGLCRI - - - - - - - - - - - S111 PGGLCRIS ASGPESL -2.0e-6 - - - - - -1.2e-9 - - - -0.52 S113 GLCRISAS GPESLLG - - - - - - - - - - - S140 SKVLLGFS SDESDVE -4.5e-5 - - - - -4.5e-5 - - - - - S141 KVLLGFSS DESDVEA - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S7
S13
S19
S27
S95
T103
S111
S113
S140
S141
S144
S164
S185
S187
T209
Y258
S259
S261
S291
S331
S352
T365
T373
S382
S399
S402
T430
S432
S753
S777
T883
S894
S911
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation CCRCC S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation COAD S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation GBM S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation HNSCC S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation LSCC S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation LUAD S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation OV S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation PDAC S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation UCEC S7 S13 S19 S27 S95 T103 S111 S113 S140 S141 S144 S164 S185 S187 T209 Y258 S259 S261 S291 S331 S352 T365 T373 S382 S399 S402 T430 S432 S753 S777 T883 S894 S911 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S7
S13
S19
S27
S95
T103
S111
S113
S140
S141
S144
S164
S185
S187
T209
Y258
S259
S261
S291
S331
S352
T365
T373
S382
S399
S402
T430
S432
S753
S777
T883
S894
S911
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S7
S13
S19
S27
S95
T103
S111
S113
S140
S141
S144
S164
S185
S187
T209
Y258
S259
S261
S291
S331
S352
T365
T373
S382
S399
S402
T430
S432
S753
S777
T883
S894
S911
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.