MAP3K11: mitogen-activated protein kinase kinase kinase 11
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5k26 chain A
5k26 chain B
5k28 chain A
5k28 chain B
6aqb chain A
6aqb chain B
6cq7 chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S11 LKSLFLKS PLGSWNG 1 9 - - - - - - - - - - - - - - - - - - 7 2 S19 PLGSWNGS GSGGGGG 1 9 - - - - - - - - - - 5 4 - - - - - - - - S35 GGGRPEGS PKAAGYA 4 182 - - - - - - 35 - - - - - - - 14 3 50 19 55 6 S493 RDGGERIS MPLDFKH 1 16 - - 8 8 - - - - - - - - - - - - - - - - S507 HRITVQAS PGLDRRR 10 1194 104 - 103 80 21 24 90 - 85 49 69 63 110 101 76 17 87 37 71 7 S524 FEVGPGDS PTFPRFR 10 1323 113 - 99 76 31 32 63 - 103 58 108 99 101 92 83 19 93 40 95 18 S548 GQAWGRQS PRRLEDS 10 1035 113 - 103 80 9 9 90 - 22 11 98 89 97 89 14 4 78 34 77 18 S569 ACWAWGPS SPKPGEA 7 136 31 - 12 10 5 4 19 - 6 4 15 13 9 8 - - - - - - S570 CWAWGPSS PKPGEAQ 8 197 - - 5 4 - - 18 - 5 4 15 14 10 8 14 3 30 15 36 16 S594 EATWYLDS DDSSPLG 1 6 - - - - - - - - - - - - - - - - 4 2 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S11 LKSLFLKS PLGSWNG - - - - - - - - - - - S19 PLGSWNGS GSGGGGG - - - - - - - - - - - S35 GGGRPEGS PKAAGYA 0.36 - - - - - - - - 0.36 - S493 RDGGERIS MPLDFKH - - - - - - - - - - - S507 HRITVQAS PGLDRRR 1.5e-4 - 1.3e-18 0.012 - 0.017 -0.077 -0.025 0.21 -0.36 - S524 FEVGPGDS PTFPRFR 0.36 - 2e-23 -2.8e-3 - -0.55 -1.3e-7 -0.036 -0.14 -0.2 3.2e-3 S548 GQAWGRQS PRRLEDS 1.2e-4 - 1.2e-21 - - -0.044 -0.2 0.001 - -8.2e-3 0.011 S569 ACWAWGPS SPKPGEA - - - - - - - - - - - S570 CWAWGPSS PKPGEAQ 0.11 - - - - - - - - 0.12 0.5 S594 EATWYLDS DDSSPLG - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S11
S19
S35
S493
S507
S524
S548
S569
S570
S594
S597
S598
S633
T680
T682
T688
S693
T702
S705
T708
S740
S748
T752
T755
S758
S770
S783
S789
S793
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation CCRCC S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation COAD S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation GBM S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation HNSCC S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation LSCC S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation LUAD S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation OV S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation PDAC S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation UCEC S11 S19 S35 S493 S507 S524 S548 S569 S570 S594 S597 S598 S633 T680 T682 T688 S693 T702 S705 T708 S740 S748 T752 T755 S758 S770 S783 S789 S793 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S11
S19
S35
S493
S507
S524
S548
S569
S570
S594
S597
S598
S633
T680
T682
T688
S693
T702
S705
T708
S740
S748
T752
T755
S758
S770
S783
S789
S793
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S11
S19
S35
S493
S507
S524
S548
S569
S570
S594
S597
S598
S633
T680
T682
T688
S693
T702
S705
T708
S740
S748
T752
T755
S758
S770
S783
S789
S793
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.