Protein: ENSP00000309629
Gene: CFL1

LinkedOmicsKB © 2022-2023 Zhang Lab

CFL1:
cofilin 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S3_____MASGVAVSDG1084650-98616481-54356863547717101428918
S23NDMKVRKSSTPEEVK93349-2118252835-32151412--4093413254
S24DMKVRKSSTPEEVKK10125578-2723839399-10259888188817618103439518
T25MKVRKSSTPEEVKKR1099657-37199710099-573354506561811939218918
S41KAVLFCLSEDKKNII101318107-10380585099-10862989011010162101438416
Y68GQTVDDPYATFVKML841358-1211--95-7244433998--9562
T70TVDDPYATFVKMLPD18------------------53
Y140HELQANCYEEVKDRC1066056-252311781-6939898035337155221611
S156LAEKLGGSAVISLEG10109465-4947928799-7445252384765313105449518
S160LGGSAVISLEGKPL_517417-----89-1710--1816--52--
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S3_____MASGVAVSDG-0.52--0.33-0.970.91--0.319.1e-4-5.5e-7
S23NDMKVRKSSTPEEVK0.023--0.160.38-0.073---1.1e-3-
S24DMKVRKSSTPEEVKK3.4e-6-0.460.2-8.8e-5-0.492.8e-30.337.4e-40.57
T25MKVRKSSTPEEVKKR1.5e-41-7.7e-62e-10-2.5e-131e-114e-100.034.4e-30.049
S41KAVLFCLSEDKKNII3.3e-12-0.0648.5e-4-0.222.3e-31.2e-8-2.1e-7-0.056
Y68GQTVDDPYATFVKML-2.4e-10-----2.3e-11-0.023----
T70TVDDPYATFVKMLPD-----------
Y140HELQANCYEEVKDRC-5.5e-3--5.4e-5--0.29-9.7e-4-0.041-0.034-
S156LAEKLGGSAVISLEG2.1e-6-0.031-9.4e-3-0.20.120.150.0823.6e-80.02
S160LGGSAVISLEGKPL_-----------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationCCRCCS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationCOADS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationGBMS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationHNSCCS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationLSCCS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationLUADS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationOVS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationPDACS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylationUCECS3S23S24T25S41Y68T70Y140S156S160proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.