Protein: ENSP00000309968
Gene: ADAM17

LinkedOmicsKB © 2022-2023 Zhang Lab

ADAM17:
ADAM metallopeptidase domain 17

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S721EMLSSMDSASVRIIK118------18-------------
S723LSSMDSASVRIIKPF19------9-------------
T735KPFPAPQTPGRLQPA101364113-8368868489-754293851101016817101438818
T761LDHQRMDTIQEDPST5151--44--71---201898161----
S767DTIQEDPSTDSHMDE823673-44--18-64335554--32124
T768TIQEDPSTDSHMDED852473-4121--18-643363576860--42173
S770QEDPSTDSHMDEDGF83548-2110--44-13548442724--732962
S785EKDPFPNSSTAAKSF989640-2514--71-8450104958881491285374516
S786KDPFPNSSTAAKSFE588--44--45-631010----42--
S791NSSTAAKSFEDLTDH998717---797390-6337696472668318101429518
Showing 1 to 10 of 11 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S721EMLSSMDSASVRIIK-----------
S723LSSMDSASVRIIKPF-----------
T735KPFPAPQTPGRLQPA1e-18-2.6e-120.11-1.4e-32.0e-67.9e-30.0286.6e-7-0.16
T761LDHQRMDTIQEDPST1.7e-3-----1.7e-3----
S767DTIQEDPSTDSHMDE0.23----0.23-----
T768TIQEDPSTDSHMDED2.1e-16-0.012--0.232.2e-111.9e-9---
S770QEDPSTDSHMDEDGF5.1e-7-0.059---2.4e-122.6e-5--2.3e-3-
S785EKDPFPNSSTAAKSF-2.7e-7-2.7e-4---6.3e-5-1.1e-5-4.3e-18-0.150.023-0.32
S786KDPFPNSSTAAKSFE-----------
S791NSSTAAKSFEDLTDH1.8e-10---0.95-0.0552.5e-97.4e-70.0152.4e-11-5.7e-7
Showing 1 to 10 of 11 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationCCRCCS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationCOADS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationGBMS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationHNSCCS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationLSCCS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationLUADS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationOVS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationPDACS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylationUCECS721S723T735T761S767T768S770S785S786S791S819proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.