Protein: ENSP00000310841
Gene: FBXO31

LinkedOmicsKB © 2022-2023 Zhang Lab

FBXO31:
F-box protein 31

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S33AETAAADSEPDTDPE814722---141335-525410871--174
T37AADSEPDTDPEEERI81746---12627-5240385471--174
Showing 1 to 2 of 2 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S33AETAAADSEPDTDPE-----------
T37AADSEPDTDPEEERI-0.006------0.006----
Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CK2A1/CSNK2A1S339.8e-30.13-0.170.14--0.2--0.87
PROGENy: TrailT370.016--0.170.15-0.14---0.58
KINASE-PSP_GSK3BS330.025---0.1-----0.12
xcell: Class-switched memory B cellT370.057--0.150.03-0.5----0.65
SBS10b (POLE mutation)T370.067--1--0.13---0.28
HALLMARK_HEME_METABOLISMT370.069--0.290.6-0.046---0.96
DISEASE-PSP_Alzheimer's_diseaseS330.073---0.35-----0.11
KINASE-PSP_RSK2/RPS6KA3T370.076---0.076------
KINASE-PSP_PKACA/PRKACAT370.076--6.6e-30.78-0.51----0.91
PATH-NP_PROLACTIN_PATHWAYT370.079---0.079------
Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS33T37proteinRNASCNVmethylationCCRCCS33T37proteinRNASCNVmethylationCOADS33T37proteinRNASCNVmethylationGBMS33T37proteinRNASCNVmethylationHNSCCS33T37proteinRNASCNVmethylationLSCCS33T37proteinRNASCNVmethylationLUADS33T37proteinRNASCNVmethylationOVS33T37proteinRNASCNVmethylationPDACS33T37proteinRNASCNVmethylationUCECS33T37proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
MAST2T372.7e-4--0.0325.7e-3-0.32---0.16
TLK2S332.7e-40.038-4.8e-30.13---0.22--0.003
FLT4T377.9e-4---0.093-2.2e-3----
NUAK1S332.1e-30.009--0.084------
ROCK1T372.8e-3--0.0220.17-0.33---0.18
TLK2T373.5e-3--0.40.016--0.72---0.003
NEK8T374.7e-3-----4.7e-3----
PRKG2S336.1e-30.21--0.035--0.17---
NME5T376.1e-3-----6.1e-3----
ABL2T376.3e-3---0.87-8.5e-3---0.053
Showing 1 to 10 of 1076 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PLPP2T37-7.6e-7---2.2e-16--0.75----0.5
ENOPH1T37-9.1e-4---0.47-0.2--1.8e-4----0.37
DUSP19S33-5.4e-3----0.53---0.024---0.052
TIGARS33-0.011-0.055--0.61-0.032---0.84---0.35
INPP5ET37-0.014----4.9e-4--1----
INPPL1S33-0.021-0.15--0.39-0.3---0.71---0.15
TIMM50T37-0.023---9.1e-3-0.051-0.82----0.82
PTP4A1T37-0.024---0.03-0.64--0.63----0.16
RNGTTS33-0.033-0.06--0.39---0.19---0.053
MTMR14S33-0.033-0.29-0.57-0.23---0.58---0.012
Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.