MADD: MAP kinase activating death domain
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T31 SSDSVAQT PELLRRY 1 18 - - - - - - 18 - - - - - - - - - - - - - S70 SVRQRRMS LRDDTSF 1 18 - - - - - - 18 - - - - - - - - - - - - - S146 GSSLQPLS ADSTPDV 1 25 - - - - - - 25 - - - - - - - - - - - - - S156 STPDVNQS PRGKRRA 6 269 - - - - 9 9 81 - 35 13 34 31 - - 37 5 - - 6 9 S230 MWRIFTGS LLVEEKS 5 186 26 - - - - - 45 - 5 3 30 25 28 24 - - - - - - S237 SLLVEEKS SALLHDL 1 9 - - - - - - 9 - - - - - - - - - - - - - T471 DLQSTPST EFNPLIY 1 9 - - - - - - 9 - - - - - - - - - - - - - S669 HAALGDAS EVEIDEL 7 424 96 - - - 19 17 36 - - - 73 67 16 17 - - 21 9 39 14 S689 AEEPGPDS ENSQENP 6 195 17 - 5 4 - - 62 - 5 3 5 4 46 44 - - - - - - S692 PGPDSENS QENPPLR 5 148 28 - - - - - 18 - 5 3 39 37 10 8 - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
T31 SSDSVAQT PELLRRY - - - - - - - - - - - S70 SVRQRRMS LRDDTSF - - - - - - - - - - - S146 GSSLQPLS ADSTPDV - - - - - - - - - - - S156 STPDVNQS PRGKRRA 0.17 - - - - 0.045 -0.93 - - - - S230 MWRIFTGS LLVEEKS -0.38 - - - - - -0.6 -0.48 - - - S237 SLLVEEKS SALLHDL - - - - - - - - - - - T471 DLQSTPST EFNPLIY - - - - - - - - - - - S669 HAALGDAS EVEIDEL -0.26 - - - - - 0.026 - - - -1.3e-4 S689 AEEPGPDS ENSQENP 2.3e-9 - - - - - - 2.3e-9 - - - S692 PGPDSENS QENPPLR 0.033 - - - - - 0.033 - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
T31
S70
S146
S156
S230
S237
T471
S669
S689
S692
S709
S762
S813
S818
S820
S826
S830
S860
S862
S882
S921
S930
S1059
T1061
S1063
T1066
S1110
S1183
S1192
S1239
S1241
S1258
S1262
S1270
S1503
S1647
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation CCRCC T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation COAD T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation GBM T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation HNSCC T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation LSCC T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation LUAD T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation OV T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation PDAC T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation UCEC T31 S70 S146 S156 S230 S237 T471 S669 S689 S692 S709 S762 S813 S818 S820 S826 S830 S860 S862 S882 S921 S930 S1059 T1061 S1063 T1066 S1110 S1183 S1192 S1239 S1241 S1258 S1262 S1270 S1503 S1647 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
T31
S70
S146
S156
S230
S237
T471
S669
S689
S692
S709
S762
S813
S818
S820
S826
S830
S860
S862
S882
S921
S930
S1059
T1061
S1063
T1066
S1110
S1183
S1192
S1239
S1241
S1258
S1262
S1270
S1503
S1647
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
T31
S70
S146
S156
S230
S237
T471
S669
S689
S692
S709
S762
S813
S818
S820
S826
S830
S860
S862
S882
S921
S930
S1059
T1061
S1063
T1066
S1110
S1183
S1192
S1239
S1241
S1258
S1262
S1270
S1503
S1647
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.