GRK2: G protein-coupled receptor kinase 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1bak chain A
3cik chain A
3krw chain A
3krx chain A
3v5w chain A
4mk0 chain A
4pnk chain A
5he1 chain A
5ukk chain A
5ukl chain A
5uuu chain A
5uvc chain A
5wg3 chain A
5wg4 chain A
5wg5 chain A
6c2y chain A
6u7c chain A
7k7l chain A
7k7z chain A
7pwd chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S38 KILLPEPS IRSVMQK 1 9 - - - - - - - - 6 3 - - - - - - - - - - S670 KMKNKPRS PVVELSK 10 1544 122 - 103 80 97 100 99 - 108 62 108 99 110 101 75 18 105 44 95 18 S685 VPLVQRGS ANGL___ 2 115 84 - - - - - - - - - - - - - - - 22 9 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S38 KILLPEPS IRSVMQK - - - - - - - - - - - S670 KMKNKPRS PVVELSK 9.3e-16 - 3.9e-17 2.9e-10 - -0.17 -0.27 0.57 -0.031 1.7e-13 2.7e-6 S685 VPLVQRGS ANGL___ - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S38
S670
S685
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S38 S670 S685 protein RNA SCNV methylation CCRCC S38 S670 S685 protein RNA SCNV methylation COAD S38 S670 S685 protein RNA SCNV methylation GBM S38 S670 S685 protein RNA SCNV methylation HNSCC S38 S670 S685 protein RNA SCNV methylation LSCC S38 S670 S685 protein RNA SCNV methylation LUAD S38 S670 S685 protein RNA SCNV methylation OV S38 S670 S685 protein RNA SCNV methylation PDAC S38 S670 S685 protein RNA SCNV methylation UCEC S38 S670 S685 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S38
S670
S685
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S38
S670
S685
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.