PRKDC: protein kinase, DNA-activated, catalytic subunit
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
5luq chain A
5luq chain B
5w1r chain A
5y3r chain C
6zfp chain A
6zh2 chain A
6zh4 chain A
6zh6 chain A
6zh8 chain A
6zha chain A
6zhe chain A
6zhe chain F
7k0y chain A
7k10 chain A
7k11 chain A
7k19 chain A
7k1b chain A
7k1j chain A
7k1k chain A
7k1n chain A
7lt3 chain C
7lt3 chain L
7nfc chain A
7nfc chain F
7nfe chain A
7otm chain A
7otp chain A
7otv chain A
7otw chain A
7oty chain A
7sgl chain A
7su3 chain A
7sud chain A
7tyr chain A
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S314 ELKKAALS ALESFLK 5 143 - - 11 11 - - 19 - 47 27 5 5 9 9 - - - - - - S503 VLPKGPES ESEDHRA 5 116 - - - - - - 27 - 11 6 34 27 - - 6 - - - 5 - S505 PKGPESES EDHRASG 1 9 9 - - - - - - - - - - - - - - - - - - - S511 ESEDHRAS GEVRTGK 7 287 - - - - 31 32 82 - 22 14 10 9 9 8 54 10 5 1 - - S687 IKYFEGVS PKSLKHS 1 8 - - 4 4 - - - - - - - - - - - - - - - - S694 SPKSLKHS PEDPEKY 2 32 - - 12 12 - - - - - - 4 4 - - - - - - - - S842 KKTKNLSS NEAISLE 3 36 15 - - - - - 9 - - - - - - - - - - - 12 - S861 RVVQMLGS LGGQINK 1 9 - - - - - - 9 - - - - - - - - - - - - - S875 KNLLTVTS SDEMMKS 2 25 - - - - - - - - - - - - 4 4 - - - - 13 4 S893 WDREKRLS FAVPFRE 10 1336 96 - 99 76 73 61 99 - 108 62 108 99 110 100 68 16 49 17 77 18
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S314 ELKKAALS ALESFLK 0.06 - - - - 0.06 - - - - - S503 VLPKGPES ESEDHRA 1.4e-8 - - - - - 1.4e-8 - - - - S505 PKGPESES EDHRASG - - - - - - - - - - - S511 ESEDHRAS GEVRTGK 3.4e-13 - - 5.9e-9 - 1.1e-6 - - 0.056 - - S687 IKYFEGVS PKSLKHS - - - - - - - - - - - S694 SPKSLKHS PEDPEKY - - - - - - - - - - - S842 KKTKNLSS NEAISLE - - - - - - - - - - - S861 RVVQMLGS LGGQINK - - - - - - - - - - - S875 KNLLTVTS SDEMMKS - - - - - - - - - - - S893 WDREKRLS FAVPFRE 1.6e-31 - -7.1e-15 6.3e-11 - 3.9e-16 2.6e-22 9.7e-15 9.6e-6 2.5e-5 0.97
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S314
S503
S505
S511
S687
S694
S842
S861
S875
S893
S1052
S1065
S1203
S1790
S2117
S2547
T2603
T2609
S2612
T2618
T2620
S2624
T2638
T2645
S2655
S2662
T2664
T2671
S2672
S2695
S2740
S2789
Y3002
S3018
S3021
T3198
S3205
S3215
S3290
S3305
S3365
S3366
Y3610
Y3614
S4026
S4084
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation CCRCC S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation COAD S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation GBM S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation HNSCC S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation LSCC S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation LUAD S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation OV S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation PDAC S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation UCEC S314 S503 S505 S511 S687 S694 S842 S861 S875 S893 S1052 S1065 S1203 S1790 S2117 S2547 T2603 T2609 S2612 T2618 T2620 S2624 T2638 T2645 S2655 S2662 T2664 T2671 S2672 S2695 S2740 S2789 Y3002 S3018 S3021 T3198 S3205 S3215 S3290 S3305 S3365 S3366 Y3610 Y3614 S4026 S4084 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S314
S503
S505
S511
S687
S694
S842
S861
S875
S893
S1052
S1065
S1203
S1790
S2117
S2547
T2603
T2609
S2612
T2618
T2620
S2624
T2638
T2645
S2655
S2662
T2664
T2671
S2672
S2695
S2740
S2789
Y3002
S3018
S3021
T3198
S3205
S3215
S3290
S3305
S3365
S3366
Y3610
Y3614
S4026
S4084
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S314
S503
S505
S511
S687
S694
S842
S861
S875
S893
S1052
S1065
S1203
S1790
S2117
S2547
T2603
T2609
S2612
T2618
T2620
S2624
T2638
T2645
S2655
S2662
T2664
T2671
S2672
S2695
S2740
S2789
Y3002
S3018
S3021
T3198
S3205
S3215
S3290
S3305
S3365
S3366
Y3610
Y3614
S4026
S4084
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.