Protein: ENSP00000314067
Gene: PAK2

LinkedOmicsKB © 2022-2023 Zhang Lab

PAK2:
p21 (RAC1) activated kinase 2

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S19PAPPVRMSSTIFSTG84118-2120--62---3029403615337187418
S20APPVRMSSTIFSTGG1078944-22201799-462779724740296105448318
S36DPLSANHSLKPLPSV714016-----36-20129843--167-9
S42HSLKPLPSVPEEKKP361--88----231444--------
S55KPRHKIISIFSGTEK10123687-5953807254-10259938680726915105448818
S58HKIISIFSGTEKGSK101493113-9976949499-1086210899101936817105449518
T60IISIFSGTEKGSKKK325----45----44--71----
S64FSGTEKGSKKKEKER948725---767671-3826151513117148202916
S75EKERPEISPPSDFEH228------18-64----------
S78RPEISPPSDFEHTIH3396-88----107----------
Showing 1 to 10 of 22 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S19PAPPVRMSSTIFSTG-1e-7-1.3e-3----1e-7-1.1e-9--0.77-6.7e-4
S20APPVRMSSTIFSTGG6.7e-3-0.026--3.2e-30.0120.021--0.49-7.9e-3
S36DPLSANHSLKPLPSV0.86----0.86-----
S42HSLKPLPSVPEEKKP1.8e-3----1.8e-3-----
S55KPRHKIISIFSGTEK-1.2e-26-8.6e-3-1.0e-4--1.9e-8-4.5e-25-7.6e-17-0.82-0.89-1.8e-5
S58HKIISIFSGTEKGSK1.7e-4-5.6e-15-0.3-8.2e-80.45-0.34-0.860.066-2.8e-3
T60IISIFSGTEKGSKKK-----------
S64FSGTEKGSKKKEKER9.1e-3---0.031-1.9e-5---5.7e-5-0.35
S75EKERPEISPPSDFEH-----------
S78RPEISPPSDFEHTIH-----------
Showing 1 to 10 of 22 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationCCRCCS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationCOADS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationGBMS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationHNSCCS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationLSCCS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationLUADS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationOVS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationPDACS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylationUCECS19S20S36S42S55S58T60S64S75S78S132T134S141T143S152T154T169T178S197S209S217S381proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.