MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
4obo chain A
4obo chain B
4obp chain A
4obp chain B
4obq chain A
4obq chain B
4rvt chain A
4rvt chain B
4u3y chain A
4u3y chain B
4u3z chain A
4u3z chain B
4u40 chain A
4u40 chain B
4u41 chain A
4u41 chain B
4u42 chain A
4u42 chain B
4u43 chain A
4u43 chain B
4u44 chain A
4u44 chain B
4u45 chain A
4u45 chain B
4zk5 chain A
4zk5 chain B
4zp5 chain A
4zp5 chain B
5di1 chain A
5di1 chain B
5j95 chain A
5j95 chain B
5w5q chain A
5w5q chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S324 DETEYEYS GSEEEEE 8 1002 104 - 80 65 - - 94 - 101 59 98 87 98 85 - - 18 7 88 18 S326 TEYEYSGS EEEEEEV 8 490 21 - 21 20 - - 59 - 79 45 35 27 39 37 - - 18 7 67 15 Y520 QLQQEQAY LLSLQHD 3 22 - - 4 4 - - - - - - - - 4 4 - - 5 1 - - S523 QEQAYLLS LQHDHRR 7 285 6 - - - - - 82 - 34 21 28 27 9 8 - - 39 16 12 3 S536 RRPHPQHS QQPPPPQ 1 22 - - - - - - 22 - - - - - - - - - - - - - S550 QQERSKPS FHAPEPK 8 878 105 - 52 49 - - 99 - 86 46 34 32 110 101 - - 78 35 44 7 S580 FRKTNHSS PEAQSKQ 8 667 39 - - - 15 12 99 - - - 103 94 8 8 83 18 65 25 83 15 S602 PVPSRSES FSNGNSE 3 86 - - - - - - 61 - - - - - - - 14 3 - - 6 2 S604 PSRSESFS NGNSESV 5 104 - - - - - - 28 - 6 3 - - 4 3 42 9 - - 7 2 S608 ESFSNGNS ESVHPAL 1 8 8 - - - - - - - - - - - - - - - - - - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S324 DETEYEYS GSEEEEE 4.3e-4 - -0.91 - - 6.4e-5 8.4e-5 0.22 - - -0.25 S326 TEYEYSGS EEEEEEV 1.8e-3 - -0.021 - - 8.2e-6 0.13 0.8 - - 2.1e-3 Y520 QLQQEQAY LLSLQHD - - - - - - - - - - - S523 QEQAYLLS LQHDHRR 0.027 - - - - 8.3e-3 -0.82 - - 0.16 - S536 RRPHPQHS QQPPPPQ - - - - - - - - - - - S550 QQERSKPS FHAPEPK 6e-33 - 3.8e-3 - - 8.4e-11 1.3e-7 6.5e-17 - 2.0e-4 - S580 FRKTNHSS PEAQSKQ 1.3e-9 - - - - - 4.4e-15 - 1.4e-3 5.1e-3 -0.088 S602 PVPSRSES FSNGNSE - - - - - - - - - - - S604 PSRSESFS NGNSESV - - - - - - - - - - - S608 ESFSNGNS ESVHPAL - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S324
S326
Y520
S523
S536
S550
S580
S602
S604
S608
T628
S629
S631
S639
S649
S656
S677
S681
S686
S688
S692
S696
S698
S700
S708
S709
S710
S712
S715
S717
T774
S791
S800
S801
S805
T809
S811
S823
T828
S830
S842
S844
S845
T846
S852
S853
S854
S855
T857
S868
S870
S877
S900
T907
S913
T915
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation CCRCC S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation COAD S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation GBM S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation HNSCC S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation LSCC S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation LUAD S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation OV S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation PDAC S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation UCEC S324 S326 Y520 S523 S536 S550 S580 S602 S604 S608 T628 S629 S631 S639 S649 S656 S677 S681 S686 S688 S692 S696 S698 S700 S708 S709 S710 S712 S715 S717 T774 S791 S800 S801 S805 T809 S811 S823 T828 S830 S842 S844 S845 T846 S852 S853 S854 S855 T857 S868 S870 S877 S900 T907 S913 T915 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S324
S326
Y520
S523
S536
S550
S580
S602
S604
S608
T628
S629
S631
S639
S649
S656
S677
S681
S686
S688
S692
S696
S698
S700
S708
S709
S710
S712
S715
S717
T774
S791
S800
S801
S805
T809
S811
S823
T828
S830
S842
S844
S845
T846
S852
S853
S854
S855
T857
S868
S870
S877
S900
T907
S913
T915
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S324
S326
Y520
S523
S536
S550
S580
S602
S604
S608
T628
S629
S631
S639
S649
S656
S677
S681
S686
S688
S692
S696
S698
S700
S708
S709
S710
S712
S715
S717
T774
S791
S800
S801
S805
T809
S811
S823
T828
S830
S842
S844
S845
T846
S852
S853
S854
S855
T857
S868
S870
S877
S900
T907
S913
T915
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.