Protein: ENSP00000315379
Gene: PRPF3

LinkedOmicsKB © 2022-2023 Zhang Lab

PRPF3:
pre-mRNA processing factor 3

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S131EVIPGPPSESPGMLT745874-7151----12763584539--63245
S133IPGPPSESPGMLTKL93839-44443719---353227239331117718
S161EERKKQLSFISPPTP218------9-----------72
S164KKQLSFISPPTPQPK22617------------------9
T167LSFISPPTPQPKTPS1081571-202010863-412383747568491065288918
T172PPTPQPKTPSSSQPE1092029-4224524645-523055509587429105449518
S175PQPKTPSSSQPERLP111------------------11-
S176QPKTPSSSQPERLPI113--------------103----
T366ARKTGIHTSTRLALI235----------9998------
S367RKTGIHTSTRLALIA615121-54--45---20191412--83--
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S131EVIPGPPSESPGMLT2.7e-6--0.029---2.6e-82.2e-6---
S133IPGPPSESPGMLTKL5.6e-18--3.2e-6--2.0e-53.5e-5-0.272.6e-7
S161EERKKQLSFISPPTP-----------
S164KKQLSFISPPTPQPK-----------
T167LSFISPPTPQPKTPS1.4e-4-0.38---0.482.3e-121.6e-3-0.9-3.7e-56.7e-5
T172PPTPQPKTPSSSQPE2.3e-5-0.360.083-0.169.6e-52.4e-9--1.4e-102.2e-4
S175PQPKTPSSSQPERLP-----------
S176QPKTPSSSQPERLPI-----------
T366ARKTGIHTSTRLALI-----------
S367RKTGIHTSTRLALIA-2.6e-5------2.6e-5----
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationCCRCCS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationCOADS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationGBMS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationHNSCCS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationLSCCS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationLUADS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationOVS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationPDACS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylationUCECS131S133S161S164T167T172S175S176T366S367Y439S552T611S619proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.