Protein: ENSP00000316578
Gene: SUZ12

LinkedOmicsKB © 2022-2023 Zhang Lab

SUZ12:
SUZ12 polycomb repressive complex 2 subunit

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S384LATRNSESLHQENKP117------------98------
S541KRTKASMSEFLESED840465-1310999-181159544439----4816
S546SMSEFLESEDGEVEQ101497122-9976838799-1086210898110101751898409518
S558VEQQRTYSSGHNRLY235------26-----54------
T570RLYFHSDTCLPLRPQ110----------55--------
S583PQEMEVDSEDEKDPE91260113-10380342999-108621039510597--105447211
S695LEKGESASPANEEIT880488-3733--45-9656108995752--32117218
S726EKALETDSVSGVSKQ621732-1212------58521411--5219-
S728ALETDSVSGVSKQSK177-------------------
Showing 1 to 9 of 9 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S384LATRNSESLHQENKP-----------
S541KRTKASMSEFLESED7.9e-3-----3.3e-50.074---0.18
S546SMSEFLESEDGEVEQ5.6e-17--0.320.2-6.7e-82.2e-201.1e-40.260.130.024
S558VEQQRTYSSGHNRLY-----------
T570RLYFHSDTCLPLRPQ-----------
S583PQEMEVDSEDEKDPE6.7e-33--1.6e-121.2e-14-1.5e-131.3e-292.1e-30--0.017.3e-4
S695LEKGESASPANEEIT6.7e-24-0.83--7.5e-111.1e-275.1e-11--0.0980.031
S726EKALETDSVSGVSKQ1.9e-11-----2e-11----
S728ALETDSVSGVSKQSK-----------
Showing 1 to 9 of 9 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationCCRCCS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationCOADS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationGBMS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationHNSCCS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationLSCCS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationLUADS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationOVS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationPDACS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylationUCECS384S541S546S558T570S583S695S726S728proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.