Protein: ENSP00000316779
Gene: BIN1

LinkedOmicsKB © 2022-2023 Zhang Lab

BIN1:
bridging integrator 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S16VTAGKIASNVQKKLT118------18-------------
S159SARHHYESLQTAKKK136------36-------------
S276GLEKQHGSNTFTVKA41959-----90---------20105214
S286FTVKAQPSDNAPAKG865515-7148--99---8578665981208907
S296APAKGNKSPSPPDGS1094848-5038242199-573470626760631392379518
S298AKGNKSPSPPDGSPA101302105-59529710099-754288829589831972329518
S303SPSPPDGSPAATPEI1056738-2524604871-27122927131270154020306
T307PDGSPAATPEIRVNH61618-5031--16-541511------129
T323PEPAGGATPGATLPK9104743-8261--99-108627871918544974338918
T327GGATPGATLPKSPSQ515416-----36---2323----323318
Showing 1 to 10 of 14 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S16VTAGKIASNVQKKLT-----------
S159SARHHYESLQTAKKK-----------
S276GLEKQHGSNTFTVKA-0.012---------0.11-0.053
S286FTVKAQPSDNAPAKG-2.6e-23--3.3e-19----2.3e-8-7.3e-3---
S296APAKGNKSPSPPDGS-1.3e-3--2.2e-60.85--6.0e-40.110.99-2.6e-30.037-0.072
S298AKGNKSPSPPDGSPA-3e-24--2.7e-3-1.7e-8--0.28-3.7e-5-4.3e-13-1.2e-60.89-3.3e-3
S303SPSPPDGSPAATPEI-2.4e-4-0.018-1.1e-7--0.17-0.003--4.9e-40.075-
T307PDGSPAATPEIRVNH-0.64--0.64--------
T323PEPAGGATPGATLPK-3.3e-3-0.027---1.9e-4-1.2e-54.5e-5--3.5e-80.9
T327GGATPGATLPKSPSQ-5.6e-7------0.053----2.8e-7
Showing 1 to 10 of 14 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationCCRCCS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationCOADS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationGBMS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationHNSCCS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationLSCCS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationLUADS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationOVS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationPDACS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylationUCECS16S159S276S286S296S298S303T307T323T327S331S333T348T536proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.