EIF4G1: eukaryotic translation initiation factor 4 gamma 1
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
1lj2 chain C
1lj2 chain D
1ug3 chain A
1ug3 chain B
2w97 chain E
2w97 chain F
4aza chain B
4aza chain D
4f02 chain C
4f02 chain F
5ehc chain B
5ei3 chain B
5eir chain B
5t46 chain B
5t46 chain D
5zk5 chain B
6zmw chain g
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S15 TGPPPAPS PGLPQPA 4 83 - - - - - - - - 27 16 5 4 - - - - 3 2 22 4 T28 PAFPPGQT APVVFST 3 146 48 - - - - - - - - - 30 26 22 20 - - - - - - S34 QTAPVVFS TPQATQM 1 9 9 - - - - - - - - - - - - - - - - - - - T35 TAPVVFST PQATQMN 1 9 9 - - - - - - - - - - - - - - - - - - - S204 MSGARTAS TPTPPQT 1 9 - - - - - - 9 - - - - - - - - - - - - - T205 SGARTAST PTPPQTG 10 876 30 - 21 20 74 78 99 - 40 25 54 42 23 20 83 16 102 42 89 18 T207 ARTASTPT PPQTGGG 10 606 93 - 31 21 37 26 45 - 26 18 20 19 27 24 82 15 19 9 78 16 T211 STPTPPQT GGGLEPQ 9 580 88 - 49 38 5 4 18 - 24 12 73 66 85 78 13 2 - - 23 2 S314 TGEPYRLS PEPTPLA 10 1095 79 - 103 80 23 13 90 - 108 62 73 65 100 93 42 7 85 37 30 5 T318 YRLSPEPT PLAEPIL 5 112 21 - 22 20 - - - - - - 14 13 9 9 - - - - 4 -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S15 TGPPPAPS PGLPQPA -0.054 - - - - -0.054 - - - - - T28 PAFPPGQT APVVFST -0.023 - - - - - -0.057 -0.19 - - - S34 QTAPVVFS TPQATQM - - - - - - - - - - - T35 TAPVVFST PQATQMN - - - - - - - - - - - S204 MSGARTAS TPTPPQT - - - - - - - - - - - T205 SGARTAST PTPPQTG -0.54 - -0.85 -0.72 - -0.017 0.042 0.11 0.2 -1.3e-6 0.27 T207 ARTASTPT PPQTGGG -0.94 - 6.5e-3 -0.021 - 0.52 0.074 0.13 0.69 - -5.1e-6 T211 STPTPPQT GGGLEPQ 1.7e-5 - 5.6e-8 - - -0.005 0.047 6.2e-5 - - - S314 TGEPYRLS PEPTPLA 7.6e-6 - 0.61 -0.47 - -5.3e-9 2.8e-14 7.9e-15 - 0.1 - T318 YRLSPEPT PLAEPIL 0.38 - 0.38 - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S15
T28
S34
T35
S204
T205
T207
T211
S314
T318
T489
S496
T505
T573
S598
T647
T667
S679
S704
S1028
T1054
S1061
S1077
S1080
S1092
S1097
S1098
S1106
T1119
S1124
S1145
S1147
S1164
T1179
S1185
S1187
S1194
S1199
S1209
T1211
S1231
S1238
S1271
S1596
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation CCRCC S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation COAD S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation GBM S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation HNSCC S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation LSCC S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation LUAD S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation OV S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation PDAC S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation UCEC S15 T28 S34 T35 S204 T205 T207 T211 S314 T318 T489 S496 T505 T573 S598 T647 T667 S679 S704 S1028 T1054 S1061 S1077 S1080 S1092 S1097 S1098 S1106 T1119 S1124 S1145 S1147 S1164 T1179 S1185 S1187 S1194 S1199 S1209 T1211 S1231 S1238 S1271 S1596 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S15
T28
S34
T35
S204
T205
T207
T211
S314
T318
T489
S496
T505
T573
S598
T647
T667
S679
S704
S1028
T1054
S1061
S1077
S1080
S1092
S1097
S1098
S1106
T1119
S1124
S1145
S1147
S1164
T1179
S1185
S1187
S1194
S1199
S1209
T1211
S1231
S1238
S1271
S1596
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S15
T28
S34
T35
S204
T205
T207
T211
S314
T318
T489
S496
T505
T573
S598
T647
T667
S679
S704
S1028
T1054
S1061
S1077
S1080
S1092
S1097
S1098
S1106
T1119
S1124
S1145
S1147
S1164
T1179
S1185
S1187
S1194
S1199
S1209
T1211
S1231
S1238
S1271
S1596
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.