Protein: ENSP00000317087
Gene: MARCHF8

LinkedOmicsKB © 2022-2023 Zhang Lab

MARCHF8:
membrane associated ring-CH-type finger 8

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S71VSSFSRTSITPSSQD18------------------53
S75SRTSITPSSQDICRI18------------------53
Showing 1 to 2 of 2 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S71VSSFSRTSITPSSQD-----------
S75SRTSITPSSQDICRI-----------
Showing 1 to 2 of 2 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Endothelial cellS75-----------
xcell: EosinophilS75-----------
xcell: Class-switched memory B cellS75-----------
xcell: Myeloid dendritic cellS75-----------
xcell: Common lymphoid progenitorS75-----------
xcell: T cell CD4+ central memoryS75-----------
xcell: Myeloid dendritic cell activatedS75-----------
cibersort: Mast cell restingS75-----------
xcell: B cellS75-----------
xcell: Common myeloid progenitorS75-----------
Showing 1 to 10 of 516 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS71S75proteinRNASCNVmethylationCCRCCS71S75proteinRNASCNVmethylationCOADS71S75proteinRNASCNVmethylationGBMS71S75proteinRNASCNVmethylationHNSCCS71S75proteinRNASCNVmethylationLSCCS71S75proteinRNASCNVmethylationLUADS71S75proteinRNASCNVmethylationOVS71S75proteinRNASCNVmethylationPDACS71S75proteinRNASCNVmethylationUCECS71S75proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ACVR2AS71-----------
ACVR2BS71-----------
ABRS71-----------
ACVR1CS71-----------
ACVR1S71-----------
ABL2S71-----------
AATKS71-----------
AAK1S71-----------
ABL1S71-----------
ACVR1BS71-----------
Showing 1 to 10 of 1076 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ALPIS71-----------
ALPLS71-----------
ACP5S71-----------
ALPGS71-----------
ACP6S71-----------
ACP4S71-----------
ACP2S71-----------
ACP1S71-----------
ACP3S71-----------
ACP7S71-----------
Showing 1 to 10 of 480 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.