Protein: ENSP00000317399
Gene: EEF1D

LinkedOmicsKB © 2022-2023 Zhang Lab

EEF1D:
eukaryotic translation elongation factor 1 delta

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S37NGPVAGASRQENGAS9868--44336337-915384778880331010544719
S44SRQENGASVILRDIA4120------18---201997----407
S60ARENIQKSLAGSSGP438------9-7355------72
S64IQKSLAGSSGPGASS117--------------143----
S65QKSLAGSSGPGASSG272------37-------296----
S70GSSGPGASSGTSGDH483------9-----88304--1311
S71SSGPGASSGTSGDHG6150----4553-11710944367----
T73GPGASSGTSGDHGEL585--------6414141312--52132
S74PGASSGTSGDHGELV393------18---54------5016
S86ELVVRIASLEVENQS7305--54----4426343218162581366014
Showing 1 to 10 of 18 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S37NGPVAGASRQENGAS1.8e-7-0.021--4.9e-143.2e-85.2e-12-2.8e-3-8.6e-11-
S44SRQENGASVILRDIA2.7e-6-----2.7e-6----
S60ARENIQKSLAGSSGP-----------
S64IQKSLAGSSGPGASS-----------
S65QKSLAGSSGPGASSG-----------
S70GSSGPGASSGTSGDH-----------
S71SSGPGASSGTSGDHG-----------
T73GPGASSGTSGDHGEL-----------
S74PGASSGTSGDHGELV0.13---------0.13
S86ELVVRIASLEVENQS0.007----0.0194.0e-5----0.074
Showing 1 to 10 of 18 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CK2A1/CSNK2A1S1621.5e-56-3e-78.9e-62.2e-162.7e-52.2e-46.6e-80.952.2e-162.2e-16
HALLMARK_E2F_TARGETSS1331.3e-17-5.5e-41.1e-30.0110.0050.060.0040.110.0249.4e-7
KINASE-PSP_CK2A1/CSNK2A1S1336.8e-17-5.3e-33.5e-35.5e-30.0787.8e-42.1e-50.530.0051.7e-4
HALLMARK_G2M_CHECKPOINTS1334.3e-16-6.4e-50.0863.4e-30.0150.0771.7e-30.280.0332e-7
HALLMARK_MYC_TARGETS_V2S1337.1e-15-0.160.0110.22.3e-38.5e-32.8e-39.6e-30.0215.6e-6
KINASE-PSP_CDK1S1332e-13-0.0210.0430.261.2e-40.0048.8e-50.020.963.5e-4
HALLMARK_DNA_REPAIRS1337.6e-13-0.470.0410.232.0e-68.6e-40.0490.160.118.3e-6
HALLMARK_TNFA_SIGNALING_VIA_NFKBS376.2e-12-0.3-0.0225.1e-75.5e-69.7e-30.752.5e-30.53
HALLMARK_MYC_TARGETS_V1S1333.3e-11-0.0392.4e-30.0950.0070.157.3e-30.180.118.3e-4
HALLMARK_UNFOLDED_PROTEIN_RESPONSES1334.9e-11-0.0330.340.330.0170.0747.0e-40.0150.0227.7e-4
Showing 1 to 10 of 4644 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationCCRCCS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationCOADS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationGBMS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationHNSCCS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationLSCCS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationLUADS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationOVS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationPDACS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylationUCECS37S44S60S64S65S70S71T73S74S86S118S119T125T129S133T147S162S197proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HDHD2S133-2.6e-14--7.7e-4-0.006-0.25-3.4e-4-0.059-1.3e-5-0.28-5.2e-3-0.059
TNS2S133-1.3e-13--4.1e-6-0.02-0.12-4.0e-4-0.063-3.6e-3-1.7e-30.76-0.01
PPM1FS133-5.3e-11--5.0e-6-1.3e-3-0.02-0.71-0.018-0.039-0.13-0.2-0.049
PTPN11S162-8.3e-10-0.590.64-0.015-0.094-0.051-7.4e-3-0.17-2.2e-16-0.26
PTPRMS133-1.6e-9--9.3e-5--0.002-0.003-0.097-0.0210.55-0.47-2.7e-3
PUDPS133-1.5e-8--5.8e-40.78-0.012-0.15-0.3-0.016-0.025-0.18-4.5e-3
NT5CS133-2.9e-8--1.5e-5-0.062-0.31-0.058-0.71-0.0520.67-0.055-1.9e-4
INPP1S133-4.7e-8--0.15-0.018-0.0510.72-0.68-2.6e-5-0.23-0.024-0.004
PPP1CBS37-5e-8--0.2--0.15-3.1e-3-4.3e-5-0.25-0.077-0.098-0.27
BPNT1S37-7.7e-8--0.36--0.011-1.9e-3-0.49-1.8e-3-0.47-0.011-0.12
Showing 1 to 10 of 4320 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.