Protein: ENSP00000317636
Gene: RECQL5

LinkedOmicsKB © 2022-2023 Zhang Lab

RECQL5:
RecQ like helicase 5

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
Y289RGVNAKAYHAGLKAS16------------------6-
S488FSRYDEGSGGSGDEG1053325-1038029339-10359151314124232252
S491YDEGSGGSGDEGRDE101069104-886563699-744293861059620284361914
S612VADIHRASKDGQPYD378----------55----3011189
S720RGEVPGGSAHYGGPS16----------------42--
S727SAHYGGPSPEKKAKS8430----121564-4827393714115611936618
S774FFCRRVESPALLASA852787-36251718---55506964--1667518
S815EDGAGGHSPAPPQTE101526113-10380939599-1086210899106978318105449518
T839CPPRDQGTPEVQPTP624217-1614--18---585254----4315
S858WKGKRPRSQQENPES4806---2519--------144--102
Showing 1 to 10 of 10 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Y289RGVNAKAYHAGLKAS-----------
S488FSRYDEGSGGSGDEG4.6e-13--0.81.4e-10-1.9e-10-----
S491YDEGSGGSGDEGRDE7.7e-39--2e-82.5e-13-3.3e-167.8e-281.1e-33--0.33-
S612VADIHRASKDGQPYD0.53--------0.53-
S720RGEVPGGSAHYGGPS-----------
S727SAHYGGPSPEKKAKS9.7e-21----1.8e-72.7e-16-0.057-7.4e-4
S774FFCRRVESPALLASA8.6e-8-0.035---7.4e-51.9e-5--0.72
S815EDGAGGHSPAPPQTE6.1e-25--0.161.3e-6-1.1e-169e-15-0.0042e-85.4e-110.7
T839CPPRDQGTPEVQPTP3.5e-4-----3.3e-6---0.69
S858WKGKRPRSQQENPES2.7e-3--2.7e-3-------
Showing 1 to 10 of 10 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationCCRCCY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationCOADY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationGBMY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationHNSCCY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationLSCCY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationLUADY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationOVY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationPDACY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylationUCECY289S488S491S612S720S727S774S815T839S858proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.