SF3B2: splicing factor 3b subunit 2
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2do5 chain A
5z56 chain 2
5z57 chain 2
5z58 chain 2
6ah0 chain 2
6ahd chain 2
6ff4 chain 8
6ff7 chain 8
6qx9 chain B2
6y50 chain 8
6y53 chain 8
6y5q chain 8
7abg chain T
7abh chain T
7abi chain T
7dvq chain 2
7evo chain 2
7onb chain I
7q3l chain B
7q4o chain B
7q4p chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S171 AKQQGDHS LKEHELL 4 113 - - - - - - 18 - - - 34 33 - - - - 8 4 12 4 T201 QEIAKMGT PVPRPPQ 1 69 - - - - - - - - - - - - - - - - - - 60 9 T217 MGQIGVRT PLGPRVA 6 170 30 - 4 3 - - - - - - 20 17 22 19 - - 8 3 42 2 S289 SRQEEMNS QQEEEEM 10 648 28 - 24 16 4 5 17 - 73 40 108 99 84 77 7 1 12 7 39 7 T298 QEEEEMET DARSSLG 1 8 8 - - - - - - - - - - - - - - - - - - - S302 EMETDARS SLGQSAS 3 81 9 - - - - - - - - - 30 28 - - - - - - 11 3 S303 METDARSS LGQSASE 9 721 78 - 9 8 45 44 54 - 6 3 84 77 75 69 61 15 - - 75 18 S307 ARSSLGQS ASETEED 10 611 77 - 11 11 45 44 81 - 13 6 54 50 18 16 63 14 18 10 66 14 S309 SSLGQSAS ETEEDTV 10 875 113 - 36 20 51 56 9 - 74 41 93 86 106 98 57 12 6 2 13 2 T311 LGQSASET EEDTVSV 10 725 89 - 16 16 54 53 62 - 46 28 50 47 27 23 34 8 69 27 61 15
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S171 AKQQGDHS LKEHELL -0.011 - - - - - -0.011 - - - - T201 QEIAKMGT PVPRPPQ - - - - - - - - - - - T217 MGQIGVRT PLGPRVA 1.0e-6 - - - - - 2.2e-4 1.3e-3 - - - S289 SRQEEMNS QQEEEEM 5.4e-21 - -5.7e-7 - - 1.8e-8 3.5e-25 5.8e-15 - - - T298 QEEEEMET DARSSLG - - - - - - - - - - - S302 EMETDARS SLGQSAS 8e-10 - - - - - 8e-10 - - - - S303 METDARSS LGQSASE 2.1e-28 - - 1.6e-3 - - 5.7e-22 1.1e-21 -0.48 - 2.2e-3 S307 ARSSLGQS ASETEED 7.4e-9 - - 2.2e-4 - - 5.6e-11 - 0.32 - 0.75 S309 SSLGQSAS ETEEDTV 1.5e-10 - -0.024 2.2e-3 - -0.027 2.1e-9 1.8e-17 9.4e-3 - - T311 LGQSASET EEDTVSV 0.79 - - 2.9e-5 - -2e-7 0.17 1.0e-4 - -0.015 -0.26
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S171
T201
T217
S289
T298
S302
S303
S307
S309
T311
T315
S317
S343
S344
S346
S347
S357
S362
S416
S431
S435
S436
S655
S778
T780
T785
S861
S883
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation CCRCC S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation COAD S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation GBM S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation HNSCC S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation LSCC S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation LUAD S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation OV S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation PDAC S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation UCEC S171 T201 T217 S289 T298 S302 S303 S307 S309 T311 T315 S317 S343 S344 S346 S347 S357 S362 S416 S431 S435 S436 S655 S778 T780 T785 S861 S883 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S171
T201
T217
S289
T298
S302
S303
S307
S309
T311
T315
S317
S343
S344
S346
S347
S357
S362
S416
S431
S435
S436
S655
S778
T780
T785
S861
S883
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S171
T201
T217
S289
T298
S302
S303
S307
S309
T311
T315
S317
S343
S344
S346
S347
S357
S362
S416
S431
S435
S436
S655
S778
T780
T785
S861
S883
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.