SUPT6H: SPT6 homolog, histone chaperone and transcription elongation factor
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
6gme chain A
6gme chain B
6gmh chain M
6ted chain M
7oop chain M
7opc chain M
7opd chain M
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S73 EGEEDEGS DSGDSED 8 731 113 - 103 80 76 76 99 - 6 3 9 9 - - - - 105 44 8 - S75 EEDEGSDS GDSEDDV 9 1262 113 - 103 80 76 76 99 - 97 54 108 97 106 96 - - 105 44 5 3 S78 EGSDSGDS EDDVGHK 9 896 113 - 99 76 4 5 90 - 97 54 5 4 102 92 - - 105 44 6 - T90 GHKKRKRT SFDDRLE 1 9 - - - - - - 9 - - - - - - - - - - - - - S91 HKKRKRTS FDDRLED 10 1174 105 - 103 80 21 32 46 - 103 58 94 86 101 94 75 18 105 44 7 2 S125 YRRVKKMS DDEDDDE 10 1448 113 - 103 80 88 91 99 - 108 62 108 99 110 101 20 4 105 44 95 18 Y135 EDDDEEEY GKEEHEK 1 7 7 - - - - - - - - - - - - - - - - - - - S267 KKRVSRRS IFEMYEP 3 89 - - - - - - 46 - - - 15 13 - - 13 2 - - - - S302 PERFQLRS IPVKGAE 1 50 - - - - - - - - - - - - 26 24 - - - - - - T327 IYRNAFAT PTISLQE 1 8 - - - - - - - - - - - - - - - - - - 5 3
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S73 EGEEDEGS DSGDSED -0.8 - -6.1e-10 8.2e-9 - - - - - 0.39 - S75 EEDEGSDS GDSEDDV 3e-31 - -6.1e-10 8.2e-9 - 1.2e-11 6.2e-30 3.9e-23 - 0.39 - S78 EGSDSGDS EDDVGHK 2.8e-11 - -0.01 - - 1.2e-8 - 9.8e-21 - 0.41 - T90 GHKKRKRT SFDDRLE - - - - - - - - - - - S91 HKKRKRTS FDDRLED -0.05 - 0.003 0.81 - 0.7 -5.6e-8 -0.028 0.34 -0.035 - S125 YRRVKKMS DDEDDDE 3.8e-21 - -1.9e-3 4.3e-13 - 1.5e-7 1.1e-24 3.7e-22 - -1.4e-3 -0.25 Y135 EDDDEEEY GKEEHEK - - - - - - - - - - - S267 KKRVSRRS IFEMYEP - - - - - - - - - - - S302 PERFQLRS IPVKGAE 7.2e-8 - - - - - - 7.2e-8 - - - T327 IYRNAFAT PTISLQE - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S73
S75
S78
T90
S91
S125
Y135
S267
S302
T327
T329
S331
S335
S456
Y554
T559
T619
Y1515
T1523
S1525
S1526
S1527
S1528
T1530
T1532
S1535
T1539
T1697
S1701
S1703
S1708
T1709
S1712
T1718
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation CCRCC S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation COAD S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation GBM S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation HNSCC S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation LSCC S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation LUAD S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation OV S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation PDAC S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation UCEC S73 S75 S78 T90 S91 S125 Y135 S267 S302 T327 T329 S331 S335 S456 Y554 T559 T619 Y1515 T1523 S1525 S1526 S1527 S1528 T1530 T1532 S1535 T1539 T1697 S1701 S1703 S1708 T1709 S1712 T1718 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S73
S75
S78
T90
S91
S125
Y135
S267
S302
T327
T329
S331
S335
S456
Y554
T559
T619
Y1515
T1523
S1525
S1526
S1527
S1528
T1530
T1532
S1535
T1539
T1697
S1701
S1703
S1708
T1709
S1712
T1718
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S73
S75
S78
T90
S91
S125
Y135
S267
S302
T327
T329
S331
S335
S456
Y554
T559
T619
Y1515
T1523
S1525
S1526
S1527
S1528
T1530
T1532
S1535
T1539
T1697
S1701
S1703
S1708
T1709
S1712
T1718
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.