Protein: ENSP00000319831

DEF6:: DEF6 guanine nucleotide exchange factor

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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				BRCA		CCRCC		COAD		GBM		HNSCC		LSCC		LUAD		OV		PDAC		UCEC
Site	Sequence	Cohorts	Total	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N	T	N
S537	QRKLRQASTNVKHWN	2	18	-	-	-	-	-	-	-	-	7	2	5	4	-	-	-	-	-	-	-	-
S566	KRPVTSSSFSGFQPP	2	128	-	-	-	-	-	-	-	-	44	26	30	28	-	-	-	-	-	-	-	-
S568	PVTSSSFSGFQPPLL	1	37	-	-	-	-	-	-	-	-	25	12	-	-	-	-	-	-	-	-	-	-
S580	PLLAHRDSSLKRLTR	8	671	61	-	9	8	-	-	71	-	80	45	54	51	89	81	-	-	79	34	7	2
S581	LLAHRDSSLKRLTRW	6	112	6	-	4	2	-	-	9	-	25	12	24	22	4	4	-	-	-	-	-	-
S590	KRLTRWGSQGNRTPS	10	1313	100	-	95	72	87	92	54	-	108	62	108	99	94	84	50	9	93	38	54	14
T595	WGSQGNRTPSPNSNE	9	410	23	-	16	6	81	89	9	-	22	14	25	25	28	24	-	-	13	7	24	4
S597	SQGNRTPSPNSNEQQ	10	807	81	-	9	8	53	37	91	-	45	28	35	33	72	65	63	12	50	23	84	18
S600	NRTPSPNSNEQQKSL	3	101	25	-	-	-	-	-	-	-	-	-	-	-	23	21	-	-	24	8	-	-
S606	NSNEQQKSLNGGDEA	7	352	-	-	4	4	-	-	26	-	82	44	34	32	35	32	-	-	28	13	18	-

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Tumor and normal comparison

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Site	Sequence	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
S537	QRKLRQASTNVKHWN	-	-	-	-	-	-	-	-	-	-	-
S566	KRPVTSSSFSGFQPP	-0.98	-	-	-	-	0.82	-0.8	-	-	-	-
S568	PVTSSSFSGFQPPLL	0.96	-	-	-	-	0.96	-	-	-	-	-
S580	PLLAHRDSSLKRLTR	1.6e-7	-	-	-	-	7.4e-6	1.7e-4	2.1e-7	-	-3.1e-3	-
S581	LLAHRDSSLKRLTRW	0.016	-	-	-	-	0.032	0.2	-	-	-	-
S590	KRLTRWGSQGNRTPS	1.3e-29	-	1.2e-19	1.4e-4	-	1.4e-7	0.38	1.8e-10	-	5.9e-3	0.08
T595	WGSQGNRTPSPNSNE	1.3e-15	-	-	6.1e-4	-	1.1e-5	0.12	4.4e-11	-	-	-
S597	SQGNRTPSPNSNEQQ	1.6e-13	-	-	1.9e-6	-	2.1e-4	2.4e-6	0.23	0.46	4.5e-3	0.12
S600	NRTPSPNSNEQQKSL	-0.83	-	-	-	-	-	-	-0.83	-	-	-
S606	NSNEQQKSLNGGDEA	0.81	-	-	-	-	4.3e-4	-0.43	-0.89	-	-2.1e-3	-

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* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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			Signed p-values
Phenotype	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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			Signed p-values
Kinase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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			Signed p-values
Phosphatase	Site	Meta P	BRCA	CCRCC	COAD	GBM	HNSCC	LSCC	LUAD	OV	PDAC	UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Protein: ENSP00000319831Gene: DEF6

Lollipop plot

Phosphosite detection coverage

Tumor and normal comparison

Phenotype and mutation association

Cis-association

Kinase association

Phosphatase association

Protein: ENSP00000319831
Gene: DEF6