Protein: ENSP00000321221
Gene: SH2B1

LinkedOmicsKB © 2022-2023 Zhang Lab

SH2B1:
SH2B adaptor protein 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S88ARASGSLSPPILAPL92658-44191769-2212292688204--69
S96PPILAPLSPGAEISP10118097-9068434579-10862107999886561333156516
S123PLAVLGPSRSSEDLA69416-12445----5588--189--
S125AVLGPSRSSEDLAGP10144395-86649710099-1025910395106986215105449518
S126VLGPSRSSEDLAGPL612415---91818---101089--207--
T218RGLVSDGTSPGERWT19----45--------------
S219GLVSDGTSPGERWTH1091497-7560352862-5534605571652957731669
T225TSPGERWTHRFERLR19----45--------------
S279GGVAGPPSGGGGQPQ17------------------52
S315FFVPPKASRPRLSIP2248-88----------------
Showing 1 to 10 of 20 rows
1025
rows per page

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S88ARASGSLSPPILAPL-2.2e-5-----3.1e-5-0.067----
S96PPILAPLSPGAEISP-1.1e-22--0.54-5.2e-4--3.7e-18-4.8e-11-3.5e-15-0.330.011-0.036
S123PLAVLGPSRSSEDLA-----------
S125AVLGPSRSSEDLAGP-1.6e-49--0.54-9.9e-21--1.6e-8-9.5e-18-7.9e-160.34-6.4e-11-6.0e-5
S126VLGPSRSSEDLAGPL-----------
T218RGLVSDGTSPGERWT-----------
S219GLVSDGTSPGERWTH5.7e-3-9.7e-110.35-3.5e-9-2.3e-30.52--3.5e-5-
T225TSPGERWTHRFERLR-----------
S279GGVAGPPSGGGGQPQ-----------
S315FFVPPKASRPRLSIP-----------
Showing 1 to 10 of 20 rows
1025
rows per page

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationCCRCCS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationCOADS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationGBMS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationHNSCCS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationLSCCS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationLUADS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationOVS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationPDACS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylationUCECS88S96S123S125S126T218S219T225S279S315S320S325S376T383S384T404S415S417S430S580proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.