PDLIM5: PDZ and LIM domain 5
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2dar chain A
2uzc chain A
2uzc chain B
2uzc chain C
2uzc chain D
2uzc chain E
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S32 NMPLTISS LKDGGKA 5 105 - - - - - - - - 37 24 5 4 4 4 - - 8 3 11 5 S52 RIGDVVLS IDGINAQ 1 10 - - - - - - - - - - 5 5 - - - - - - - - S76 KIKGCTGS LNMTLQR 1 18 - - - - - - - - 11 7 - - - - - - - - - - T80 CTGSLNMT LQRASAA 6 173 47 - 5 4 - - 9 - - - 30 28 - - - - 26 11 11 2 T110 VVKPVPIT SPAVSKV 3 60 23 - 17 14 - - - - - - - - - - - - - - 6 - S111 VKPVPITS PAVSKVT 10 1054 49 - 54 33 93 95 99 - 70 41 49 45 45 40 70 15 100 43 95 18 S119 PAVSKVTS TNNMAYN 9 444 7 - - - 39 33 54 - 34 21 5 5 12 12 7 1 76 31 89 18 T120 AVSKVTST NNMAYNK 7 495 73 - 94 72 - - - - 24 11 44 41 30 29 - - 49 22 6 - S134 KAPRPFGS VSSPKVT 8 461 88 - - - 19 16 63 - 55 33 5 4 - - 49 11 69 30 17 2 S136 PRPFGSVS SPKVTSI 2 35 9 - - - - - - - - - - - - - - - 17 9 - -
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S32 NMPLTISS LKDGGKA -2.2e-3 - - - - -2.2e-3 - - - - - S52 RIGDVVLS IDGINAQ - - - - - - - - - - - S76 KIKGCTGS LNMTLQR - - - - - - - - - - - T80 CTGSLNMT LQRASAA 2.2e-6 - - - - - 1.3e-3 - - 5.0e-4 - T110 VVKPVPIT SPAVSKV - - - - - - - - - - - S111 VKPVPITS PAVSKVT 1.7e-4 - -4.4e-3 1.1e-8 - -1.0e-4 0.09 3.8e-4 0.01 0.084 0.035 S119 PAVSKVTS TNNMAYN 1.7e-19 - - 3.0e-6 - 1.4e-6 - - - 1.4e-7 9.9e-4 T120 AVSKVTST NNMAYNK -0.11 - -3.7e-19 - - 0.52 5.1e-4 8.9e-4 - 1.6e-5 - S134 KAPRPFGS VSSPKVT 0.28 - - - - 0.23 - - -0.62 0.25 - S136 PRPFGSVS SPKVTSI - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S32
S52
S76
T80
T110
S111
S119
T120
S134
S136
S137
T208
T210
S211
S214
T216
S217
S228
Y251
T255
S257
S260
T275
S282
T290
S309
S313
S319
S322
S325
S329
S332
S335
T341
S342
S354
T355
S360
S362
S372
T373
S377
S379
T381
S385
S391
T417
S438
S593
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation CCRCC S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation COAD S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation GBM S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation HNSCC S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation LSCC S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation LUAD S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation OV S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation PDAC S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation UCEC S32 S52 S76 T80 T110 S111 S119 T120 S134 S136 S137 T208 T210 S211 S214 T216 S217 S228 Y251 T255 S257 S260 T275 S282 T290 S309 S313 S319 S322 S325 S329 S332 S335 T341 S342 S354 T355 S360 S362 S372 T373 S377 S379 T381 S385 S391 T417 S438 S593 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S32
S52
S76
T80
T110
S111
S119
T120
S134
S136
S137
T208
T210
S211
S214
T216
S217
S228
Y251
T255
S257
S260
T275
S282
T290
S309
S313
S319
S322
S325
S329
S332
S335
T341
S342
S354
T355
S360
S362
S372
T373
S377
S379
T381
S385
S391
T417
S438
S593
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
Loading, please wait
all sites
S32
S52
S76
T80
T110
S111
S119
T120
S134
S136
S137
T208
T210
S211
S214
T216
S217
S228
Y251
T255
S257
S260
T275
S282
T290
S309
S313
S319
S322
S325
S329
S332
S335
T341
S342
S354
T355
S360
S362
S372
T373
S377
S379
T381
S385
S391
T417
S438
S593
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.