Protein: ENSP00000322706
Gene: HMGCS1

LinkedOmicsKB © 2022-2023 Zhang Lab

HMGCS1:
3-hydroxy-3-methylglutaryl-CoA synthase 1

Lollipop plot

Phosphosites location and occurrence

Select Y-axis:

* Hover over the dots to see sequence motif and cohorts.

Structure

Phosphosite detection coverage

The frequency of phosphosite detection in the number of cohorts and tumor and normal samples

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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S4____MPGSLPLNAEA101270113-3734788363-108621039410697471191389015
Y295NRDKNSIYSGLEAFG129----------1514--------
T476RPTPNDDTLDEGVGL19----------54--------
T490LVHSNIATEHIPSPA37952-44----127----------
S495IATEHIPSPAKKVPR99318-44736997-885084677973--101427616
S516EPEAAVISNGEH___101481122-10380807299-1076210899106976816105449518
Showing 1 to 6 of 6 rows

Tumor and normal comparison

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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S4____MPGSLPLNAEA9.1e-6--0.131.0e-4--7.5e-71.9e-22-0.18-0.610.0227.8e-7
Y295NRDKNSIYSGLEAFG-----------
T476RPTPNDDTLDEGVGL-----------
T490LVHSNIATEHIPSPA-----------
S495IATEHIPSPAKKVPR1.5e-33--1.2e-9-0.191.2e-211.4e-3-1.1e-74.0e-5
S516EPEAAVISNGEH___-6.6e-10-0.38-0.64--1.5e-6-0.073-3e-8-0.011-6.2e-40.81
Showing 1 to 6 of 6 rows

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

Phenotype and mutation association

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Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_G2M_CHECKPOINTS4954.6e-29--1.6e-31.8e-60.0485.9e-52.2e-16-5.5e-32.6e-6
HALLMARK_E2F_TARGETSS4952.7e-27--1.3e-39.6e-60.151.1e-42.2e-16-0.0053.2e-6
KINASE-PSP_CDK2S4951.8e-24--1.4e-52.4e-50.0170.0252.2e-16-0.134.2e-5
HALLMARK_CHOLESTEROL_HOMEOSTASISS43e-241.3e-40.0473.2e-40.761.2e-81.4e-64.6e-40.495.1e-42.2e-5
PERT-PSP_NOCODAZOLES4952.5e-16--1.1e-40.731.2e-39.8e-49.7e-8-0.18.0e-5
HALLMARK_SPERMATOGENESISS4956e-15--0.0076.1e-80.0211.3e-31.1e-4-0.540.012
KINASE-PSP_CDK1S4956.4e-15--2.9e-40.0980.0392.6e-35.2e-8-0.341.1e-4
HALLMARK_MTORC1_SIGNALINGS47e-144.1e-37.7e-37.6e-30.071.2e-34.2e-40.003-0.460.819.7e-6
HALLMARK_MYC_TARGETS_V2S4953.6e-13--0.0820.250.0362.6e-44.9e-6-0.0281.3e-4
HALLMARK_MITOTIC_SPINDLES4953.4e-11--0.928.2e-60.730.0581.4e-6-6.8e-31.4e-3
Showing 1 to 10 of 1548 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.

Cis-association

BRCAS4Y295T476T490S495S516proteinRNASCNVmethylationCCRCCS4Y295T476T490S495S516proteinRNASCNVmethylationCOADS4Y295T476T490S495S516proteinRNASCNVmethylationGBMS4Y295T476T490S495S516proteinRNASCNVmethylationHNSCCS4Y295T476T490S495S516proteinRNASCNVmethylationLSCCS4Y295T476T490S495S516proteinRNASCNVmethylationLUADS4Y295T476T490S495S516proteinRNASCNVmethylationOVS4Y295T476T490S495S516proteinRNASCNVmethylationPDACS4Y295T476T490S495S516proteinRNASCNVmethylationUCECS4Y295T476T490S495S516proteinRNASCNVmethylation

* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.

Kinase association

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Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.

Phosphatase association

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Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PALD1S495-2e-11---0.23-0.019-1.1e-3-3.4e-5-6.3e-3--9.2e-3-0.15
TNS2S4-1.8e-8-0.094-2.7e-3-0.5-0.09-4.9e-3-2.4e-3-0.670.96-0.36-3.1e-4
PALD1S4-2.4e-80.92-0.0660.77-0.11-1.1e-3-1.6e-4-0.22-0.79-6.2e-3-8.6e-4
INPP5DS495-4.9e-8---0.16-1.6e-5-1.2e-4-4.7e-3-0.25--0.270.84
PTPRCS495-6.1e-8---0.21-5.2e-7-1.6e-5-1.8e-30.37--0.0460.63
PPM1MS495-8.9e-8---0.035-0.077-0.48-1.2e-3-0.021--6.1e-3-0.21
TNS2S495-7.5e-7---0.15-0.028-0.93-0.011-0.035--6.9e-3-0.043
PTPN18S4-8.8e-7-0.029-0.082-0.49-0.061-2.0e-4-8.3e-60.430.75-0.22-0.44
PTPRMS495-1.8e-6----0.0470.89-2.8e-4-0.27--0.019-5.7e-3
PPM1KS495-3.7e-6----0.42-0.071-0.29-7.9e-3--8.1e-3-0.018
Showing 1 to 10 of 1440 rows

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.