RBBP8: RB binding protein 8, endonuclease
Lollipop plot
Phosphosites location and occurrence
Select Y-axis:
Sample number
Cohort number
* Hover over the dots to see sequence motif and cohorts.
Structure
2l4z chain A
4d2h chain A
4d2h chain B
4d2h chain C
4d2h chain D
4d2h chain E
4d2h chain F
4d2h chain G
4d2h chain H
7bgf chain A
7bgf chain B
Phosphosite detection coverage
The frequency of phosphosite detection in the number of cohorts and tumor and normal samples
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BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Site
Sequence
Cohorts
Total
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
T
N
S163 EEDVIPDS PITAFSF 9 820 88 - 78 72 8 10 - - 103 58 88 63 97 85 10 1 16 7 23 13 S233 DTYDQSQS PMAKAHG 1 22 - - - - - - - - - - - - - - - - - - 17 5 T245 AHGTSSYT PDKSSFN 6 178 8 - - - - - 18 - 44 30 10 9 - - 35 8 - - 5 11 S311 DSLRFSDS TSKTPPQ 1 15 - - - - - - - - - - - - - - - - - - 13 2 S313 LRFSDSTS KTPPQEE 1 9 - - - - 7 2 - - - - - - - - - - - - - - T315 FSDSTSKT PPQEELP 10 1251 116 - 90 76 16 11 45 - 108 62 98 89 96 89 83 19 98 42 95 18 T323 PPQEELPT RVSSPVF 1 10 - - - - - - - - - - 5 5 - - - - - - - - S326 EELPTRVS SPVFGAT 2 40 32 - - - - - - - 4 4 - - - - - - - - - - S327 ELPTRVSS PVFGATS 10 1498 122 - 99 76 76 85 90 - 108 62 108 99 110 101 82 18 105 44 95 18 S335 PVFGATSS IKSGLDL 1 20 - - - - - - - - - - - - - - - - - - 18 2
Tumor and normal comparison
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Site
Sequence
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
S163 EEDVIPDS PITAFSF 4.1e-9 - -0.37 - - -0.83 5.9e-12 1.2e-7 - - 0.037 S233 DTYDQSQS PMAKAHG - - - - - - - - - - - T245 AHGTSSYT PDKSSFN 6.1e-8 - - - - 6.1e-8 - - - - - S311 DSLRFSDS TSKTPPQ - - - - - - - - - - - S313 LRFSDSTS KTPPQEE - - - - - - - - - - - T315 FSDSTSKT PPQEELP 2.4e-29 - -2.3e-19 - - 1.2e-14 1.7e-27 9.4e-15 0.046 5.9e-11 0.002 T323 PPQEELPT RVSSPVF - - - - - - - - - - - S326 EELPTRVS SPVFGAT - - - - - - - - - - - S327 ELPTRVSS PVFGATS 2.6e-36 - -6.4e-18 7.5e-14 - 3.6e-17 5.2e-33 1.7e-24 7.4e-3 -0.76 8.2e-4 S335 PVFGATSS IKSGLDL - - - - - - - - - - -
* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.
Phenotype and mutation association
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all sites
S163
S233
T245
S311
S313
T315
T323
S326
S327
S335
S345
S347
S349
S377
S379
S464
S539
S549
S555
S568
S593
S649
S656
S723
S745
S789
T847
S889
all
clinical
pathway
cell type
genomic
mutation
Signed p-values
Phenotype
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots.
Cis-association
BRCA S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation CCRCC S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation COAD S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation GBM S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation HNSCC S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation LSCC S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation LUAD S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation OV S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation PDAC S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation UCEC S163 S233 T245 S311 S313 T315 T323 S326 S327 S335 S345 S347 S349 S377 S379 S464 S539 S549 S555 S568 S593 S649 S656 S723 S745 S789 T847 S889 protein RNA SCNV methylation
* The circles can be clicked to show the scatter plots. The color and size of the circles correlate with the Spearman correlation coefficients.
Kinase association
Protein
RNA
SCNV
methylation
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all sites
S163
S233
T245
S311
S313
T315
T323
S326
S327
S335
S345
S347
S349
S377
S379
S464
S539
S549
S555
S568
S593
S649
S656
S723
S745
S789
T847
S889
Signed p-values
Kinase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.
Phosphatase association
Protein
RNA
SCNV
methylation
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all sites
S163
S233
T245
S311
S313
T315
T323
S326
S327
S335
S345
S347
S349
S377
S379
S464
S539
S549
S555
S568
S593
S649
S656
S723
S745
S789
T847
S889
Signed p-values
Phosphatase
Site
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found
* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots.